Aknetrent 20mg Capsule contains Isotretinoin, a powerful retinoid medication derived from vitamin A. This prescription-only treatment is designed for severe, treatment-resistant nodular acne that hasn’t responded to conventional therapies including antibiotics.
Uses
Aknetrent is primarily used to treat severe nodular or cystic acne that hasn’t responded to other treatments. It’s specifically indicated for acne with significant scarring potential. In some cases, it may be prescribed for other severe skin disorders or certain rare skin cancers as determined by a dermatologist.
Benefits
- Effectively treats severe nodular and cystic acne
- Reduces sebum (oil) production in skin glands
- Decreases inflammation associated with acne
- Prevents formation of new acne lesions
- Reduces bacteria that contribute to acne
- Minimizes potential for permanent scarring
- Provides long-lasting or permanent remission in many patients
- Improves quality of life and psychological wellbeing
- Resolves acne resistant to other treatments
How It Works
Isotretinoin works by reducing sebaceous gland size and oil production by up to 90%. It normalizes follicular keratinization, preventing pore blockage and subsequent acne formation. The medication also has anti-inflammatory properties and indirectly reduces P. acnes bacteria by creating an environment less conducive to their growth.
Dosage
Patient Weight | Starting Dosage | Maintenance Dosage |
---|---|---|
<60 kg | 20mg daily | 0.5-1 mg/kg/day |
>60 kg | 20-40mg daily | 0.5-1 mg/kg/day |
Take with food containing adequate fat to improve absorption. Treatment typically lasts 15-20 weeks. Second courses considered only after 8 weeks if needed.
Duration of Action
Aknetrent begins showing visible improvement within 2-4 weeks, with significant results appearing after 8-12 weeks. The full therapeutic effect develops over the 15-20 week treatment course. Many patients experience long-lasting or permanent remission after completing a full course.
Side Effects
Common side effects include dry lips, dry skin, nose bleeds, joint pain, and temporary worsening of acne. Less common effects include headaches, muscle pain, and sensitivity to sunlight. Rare but serious effects may include mood changes, vision problems, or severe digestive symptoms requiring immediate medical attention.
Warning
Isotretinoin causes severe birth defects. Female patients must use two reliable forms of contraception and undergo monthly pregnancy testing. Aknetrent may increase risk of depression, suicidal thoughts, inflammatory bowel disease, and elevated lipid levels. Regular blood tests are required. Never donate blood during and for one month after treatment.
Pregnancy and Breastfeeding
Aknetrent is absolutely contraindicated during pregnancy due to extremely high risk of severe birth defects. Women of childbearing potential must participate in a pregnancy prevention program. Isotretinoin passes into breast milk and should not be used while breastfeeding due to potential harm to the infant.
Interaction
- May decrease effectiveness of progesterone-only contraceptives
- Increased risk of pseudotumor cerebri with tetracycline antibiotics
- Potential for increased vitamin A toxicity with vitamin A supplements
- Possible reduced effectiveness with certain seizure medications
- May enhance blood thinning effects of anticoagulants
Precaution
Requires medical supervision through regular monitoring. Avoid waxing, dermabrasion, and aggressive skin treatments during and for 6 months after therapy. Use effective sunscreen due to increased photosensitivity. Monitor for mood changes, visual disturbances, or severe digestive symptoms. Do not share medication with others regardless of similar symptoms.
Important Information
Aknetrent is a powerful medication requiring strict adherence to monitoring protocols. Never purchase without prescription. Inform all healthcare providers you’re taking isotretinoin. Avoid alcohol during treatment due to potential liver interactions. Contact dermatologist immediately regarding severe side effects. Keep all follow-up appointments and required laboratory tests throughout treatment course.
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Customer questions & answers
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Where can I get 40mg of this accutane minus roaccutane and accufine I have been on 20mg for a month acne reduced a bit but now on month 2 not noticing much difference
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Q Where can I get 40mg of this accutane minus roaccutane and accufine I have been on 20mg for a mon...... Read more answer nowAsked by Mike on June 9, 2025 11:30 amA
Hello Mike👋🏼,
You can increase to a 40 mg isotretinoin capsule—standard brands like Accutane/Aknetrent offer 10 mg, 20 mg, 30 mg, and 40 mg capsules This higher strength is often prescribed if acne isn’t improving on lower doses .
To get 40 mg:
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Consult your dermatologist, explain the slow improvement on 20 mg.
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They can prescribe 40 mg capsules (usually taken once daily or split into two doses with meals).
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Ensure it's during a full course—4–6 months, with weight-based dosing (typically 0.5–1 mg/kg/day).
⚠️ Important: Isotretinoin is prescription-only with strict safety rules due to potential side effects (e.g., birth defects, liver changes). Always use full medical supervision.
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