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Aknetrent 20mg Capsule (Isotretinoin) x30

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Aknetrent 20mg is used to treat severe nodular or cystic acne, pimple that hasn’t responded to other treatments, It is also used for other skin disorders

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Availability: In Stock
SKU:AKR27836

Aknetrent 20mg Capsule contains Isotretinoin, a powerful retinoid medication derived from vitamin A. This prescription-only treatment is designed for severe, treatment-resistant nodular acne that hasn’t responded to conventional therapies including antibiotics.

Uses

Aknetrent is primarily used to treat severe nodular or cystic acne that hasn’t responded to other treatments. It’s specifically indicated for acne with significant scarring potential. In some cases, it may be prescribed for other severe skin disorders or certain rare skin cancers as determined by a dermatologist.

Benefits

  • Effectively treats severe nodular and cystic acne
  • Reduces sebum (oil) production in skin glands
  • Decreases inflammation associated with acne
  • Prevents formation of new acne lesions
  • Reduces bacteria that contribute to acne
  • Minimizes potential for permanent scarring
  • Provides long-lasting or permanent remission in many patients
  • Improves quality of life and psychological wellbeing
  • Resolves acne resistant to other treatments

How It Works

Isotretinoin works by reducing sebaceous gland size and oil production by up to 90%. It normalizes follicular keratinization, preventing pore blockage and subsequent acne formation. The medication also has anti-inflammatory properties and indirectly reduces P. acnes bacteria by creating an environment less conducive to their growth.

Dosage

Patient Weight Starting Dosage Maintenance Dosage
<60 kg 20mg daily 0.5-1 mg/kg/day
>60 kg 20-40mg daily 0.5-1 mg/kg/day

Take with food containing adequate fat to improve absorption. Treatment typically lasts 15-20 weeks. Second courses considered only after 8 weeks if needed.

Duration of Action

Aknetrent begins showing visible improvement within 2-4 weeks, with significant results appearing after 8-12 weeks. The full therapeutic effect develops over the 15-20 week treatment course. Many patients experience long-lasting or permanent remission after completing a full course.

Side Effects

Common side effects include dry lips, dry skin, nose bleeds, joint pain, and temporary worsening of acne. Less common effects include headaches, muscle pain, and sensitivity to sunlight. Rare but serious effects may include mood changes, vision problems, or severe digestive symptoms requiring immediate medical attention.

Warning

Isotretinoin causes severe birth defects. Female patients must use two reliable forms of contraception and undergo monthly pregnancy testing. Aknetrent may increase risk of depression, suicidal thoughts, inflammatory bowel disease, and elevated lipid levels. Regular blood tests are required. Never donate blood during and for one month after treatment.

Pregnancy and Breastfeeding

Aknetrent is absolutely contraindicated during pregnancy due to extremely high risk of severe birth defects. Women of childbearing potential must participate in a pregnancy prevention program. Isotretinoin passes into breast milk and should not be used while breastfeeding due to potential harm to the infant.

Interaction

  • May decrease effectiveness of progesterone-only contraceptives
  • Increased risk of pseudotumor cerebri with tetracycline antibiotics
  • Potential for increased vitamin A toxicity with vitamin A supplements
  • Possible reduced effectiveness with certain seizure medications
  • May enhance blood thinning effects of anticoagulants

Precaution

Requires medical supervision through regular monitoring. Avoid waxing, dermabrasion, and aggressive skin treatments during and for 6 months after therapy. Use effective sunscreen due to increased photosensitivity. Monitor for mood changes, visual disturbances, or severe digestive symptoms. Do not share medication with others regardless of similar symptoms.

Important Information

Aknetrent is a powerful medication requiring strict adherence to monitoring protocols. Never purchase without prescription. Inform all healthcare providers you’re taking isotretinoin. Avoid alcohol during treatment due to potential liver interactions. Contact dermatologist immediately regarding severe side effects. Keep all follow-up appointments and required laboratory tests throughout treatment course.

Product Image Highlights

Aknetrent 20mg
Aknetrent 20mg Capsule
Aknetrent
Isotretinoin

Customer questions & answers

    Where can I get 40mg of this accutane minus roaccutane and accufine I have been on 20mg for a month acne reduced a bit but now on month 2 not noticing much difference
  1. 0 votes
    Q Where can I get 40mg of this accutane minus roaccutane and accufine I have been on 20mg for a mon...... Read more answer now
    Asked by Mike on June 9, 2025 11:30 am
    A

    Hello Mike👋🏼,

    You can increase to a 40 mg isotretinoin capsule—standard brands like Accutane/Aknetrent offer 10 mg, 20 mg, 30 mg, and 40 mg capsules This higher strength is often prescribed if acne isn’t improving on lower doses .

    To get 40 mg:

    1. Consult your dermatologist, explain the slow improvement on 20 mg.

    2. They can prescribe 40 mg capsules (usually taken once daily or split into two doses with meals).

    3. Ensure it's during a full course—4–6 months, with weight-based dosing (typically 0.5–1 mg/kg/day).

    ⚠️ Important: Isotretinoin is prescription-only with strict safety rules due to potential side effects (e.g., birth defects, liver changes). Always use full medical supervision.

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Age Group Dosage Instructions
Adults (18 years and above) Typically 0.5mg to 1mg per kg body weight daily, divided into 1 or 2 doses. A common starting dose is 20mg once or twice daily depending on severity. Duration usually 16 to 24 weeks.
Adolescents (12–17 years) Similar to adults but dose is carefully calculated by dermatologist based on body weight. Generally 0.5mg per kg daily to start.
Children below 12 years Not recommended. Isotretinoin is only approved for severe acne in older adolescents and adults.

How to Use

  • Take with food for better absorption.

  • Swallow the capsule whole with a full glass of water; do not chew or crush.

  • Take at the same time every day (either once daily or divided into morning and evening doses as prescribed).

  • Follow your dermatologist’s instructions strictly.


Special Notes

  • A strict pregnancy prevention program (e.g., using effective birth control) must be followed before, during, and at least 1 month after stopping treatment — as isotretinoin can cause severe birth defects.

  • Regular blood tests are required to monitor liver function, lipids, and pregnancy tests (for females).

  • Avoid taking vitamin A supplements while on treatment, as it can increase side effects.

  • Stay out of direct sunlight and use sunscreen — skin becomes extra sensitive during treatment.


Important Information

  • Not for mild acne — used only for severe, nodular, or treatment-resistant acne.

  • Avoid waxing, dermabrasion, or laser treatments while on isotretinoin and for at least 6 months after stopping.

  • May cause dryness of lips, skin, eyes, and nose — keep moisturized.

  • Report any mood changes, vision problems, or severe headaches to your doctor immediately.

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