Augmentin 1G Tablet (Co-Amoxiclav) x14

Augmentin 1G Tablet is a prescription antibiotic medication containing the combination of amoxicillin and clavulanic acid. This dual-action formulation provides comprehensive coverage against many common bacterial pathogens while overcoming resistance mechanisms.

Uses

Augmentin 1G Tablet treats bacterial infections including respiratory tract infections, typhoid fever,  urinary tract infections, skin and soft tissue infections, bone and joint infections, dental infections, sinusitis, otitis media, and infections following surgical procedures. It’s particularly effective for infections caused by beta-lactamase producing bacteria.

Benefits

• Broad-spectrum antimicrobial activity
• Effective against beta-lactamase producing bacteria
• Treats both gram-positive and gram-negative infections
• Rapid absorption and distribution to infection sites
• Fewer treatment failures compared to amoxicillin alone
• Convenient twice-daily dosing regimen
• High clinical success rates
• Well-established safety profile

How It Works

Augmentin 1G Tablet works through a dual mechanism of action. Amoxicillin binds to penicillin-binding proteins to inhibit bacterial cell wall synthesis, causing bacterial cell death. Clavulanic acid inactivates beta-lactamase enzymes produced by resistant bacteria, preventing them from destroying amoxicillin.

Duration of Action

The medication reaches peak plasma concentrations within 1-2 hours after oral administration. Therapeutic levels are maintained in the body for approximately 12 hours, allowing for twice-daily dosing. Complete elimination occurs within 24 hours in patients with normal renal function.

Dosage

Warnings

Do not use Augmentin 1G Tablet if you have a history of allergic reactions to penicillins, cephalosporins, or other beta-lactam antibiotics. Serious and occasionally fatal hypersensitivity reactions have been reported. Stop medication immediately if you develop skin rash, itching, or difficulty breathing.

Side Effects

Common side effects include diarrhea, nausea, vomiting, indigestion, and skin rash. Less common effects include antibiotic-associated colitis, liver function abnormalities, and fungal infections. Serious but rare side effects include severe allergic reactions, Stevens-Johnson syndrome, and blood disorders.

Pregnancy and Breastfeeding

Augmentin 1G Tablet may be used during pregnancy when the potential benefits outweigh the risks. The medication passes into breast milk in small amounts. Consult your healthcare provider before using while pregnant or breastfeeding.

Interactions

• Probenecid (increases amoxicillin levels)
• Allopurinol (increased risk of skin rash)
• Oral contraceptives (reduced effectiveness)
• Anticoagulants (increased bleeding risk)
• Methotrexate (increased toxicity)
• Mycophenolate mofetil (reduced effectiveness)
• Certain antibiotics (antagonistic effects)

Precautions

Take Augmentin 1G Tablet at the start of a meal to enhance absorption and reduce stomach upset. Complete the full course of treatment even if symptoms improve. Drink plenty of fluids while taking this medication. Store tablets in a cool, dry place away from direct sunlight and moisture.

Important Information

Augmentin 1G Tablet should only be used to treat bacterial infections, not viral infections such as colds or flu. Overuse or misuse can lead to bacterial resistance. Prolonged use may result in fungal or bacterial superinfection. Report any persistent or worsening symptoms to your healthcare provider promptly.