Bristol Amiodarone 100mg is a specialized class III antiarrhythmic medication containing amiodarone hydrochloride. This potent formulation of Bristol Amiodarone is specifically designed for managing life-threatening cardiac arrhythmias and maintaining normal heart rhythm.
Uses
Bristol Amiodarone is primarily indicated for treating and preventing serious ventricular arrhythmias, including ventricular tachycardia and ventricular fibrillation. It’s also used to maintain normal sinus rhythm in patients with atrial fibrillation when other treatments have proven ineffective.
Benefits
- Controls life-threatening ventricular arrhythmias
- Maintains normal heart rhythm long-term
- Reduces risk of sudden cardiac death
- Decreases hospitalization frequency
- Provides effective rhythm control
- Improves quality of life
- Offers alternative when other treatments fail
- Provides sustained arrhythmia management
How It Works
Bristol Amiodarone functions by modifying the heart’s electrical properties, prolonging the action potential and refractory period. This mechanism helps stabilize cardiac rhythm and prevent dangerous arrhythmias.
Duration of Action
Initial effects begin within 1-3 weeks. Due to its long half-life, Bristol Amiodarone may take several weeks to reach steady-state levels. Effects can persist for months after discontinuation.
Dosage
Phase | Daily Dose | Duration |
---|---|---|
Loading | 800mg | 1-3 weeks |
Intermediate | 400mg | 4-8 weeks |
Maintenance | 200mg | Long-term |
Side Effects
Common side effects include thyroid dysfunction, pulmonary toxicity, and liver abnormalities. Regular monitoring of thyroid, liver, and lung function is essential during Bristol Amiodarone therapy.
Warning
Seek immediate medical attention for symptoms of lung toxicity (shortness of breath, cough), liver problems (yellowing of skin/eyes), or thyroid dysfunction. Regular monitoring of organ functions is mandatory.
Pregnancy and Breastfeeding
Bristol Amiodarone is contraindicated during pregnancy and breastfeeding due to potential serious risks to the fetus/infant and its long half-life.
Interactions
- Warfarin (increased bleeding risk)
- Digoxin (increased levels)
- Beta-blockers
- Calcium channel blockers
- Statins
- CYP3A4 inhibitors
Precautions
Regular eye examinations, chest X-rays, and blood tests are required. Avoid sun exposure during treatment. Monitor thyroid, liver, and lung function regularly. Avoid grapefruit products.
Important Information
Take Bristol Amiodarone exactly as prescribed. Never adjust or stop medication without medical supervision. Long-term monitoring is essential for safe use. Report any new symptoms promptly to healthcare provider.
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