CoAprovel 300mg/12.5mg Tablets X 28

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CoAprovel is a combination of irbesartan and hydrochlorothiazide. It is indicated for the treatment of essential hypertension.


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CoAprovel is a prescription medication combining irbesartan and hydrochlorothiazide, designed to treat essential hypertension in adults. It’s specifically formulated for patients whose blood pressure is not adequately controlled by either component alone, offering a synergistic approach to hypertension management.


CoAprovel is used to treat essential hypertension in adults when monotherapy with irbesartan or hydrochlorothiazide has not provided sufficient blood pressure control. It’s particularly beneficial for patients requiring a combination therapy approach to manage their hypertension effectively.


  • Provides dual-action blood pressure control
  • May offer better efficacy than monotherapy for some patients
  • Potentially reduces the number of pills patients need to take daily
  • Helps manage hypertension through complementary mechanisms
  • May improve patient adherence to treatment regimen
  • Could reduce the risk of hypertension-related complications

How it works

CoAprovel combines two active ingredients with different mechanisms of action. Irbesartan is an angiotensin II receptor antagonist that helps relax blood vessels, while hydrochlorothiazide is a diuretic that increases urine output, reducing blood volume. This dual approach effectively lowers blood pressure through complementary pathways.


The typical starting dose of CoAprovel is one tablet of 150 mg/12.5 mg once daily. If necessary, the dose can be increased to one 300 mg/12.5 mg tablet once daily. The maximum daily dose is 300 mg irbesartan/25 mg hydrochlorothiazide. It’s important to take CoAprovel as prescribed by your healthcare provider, usually at the same time each day.

Side Effects

Common side effects may include dizziness, fatigue, nausea, and elevated blood potassium levels. Less common side effects can include allergic reactions, liver problems, or changes in blood cell counts. If you experience severe side effects or signs of an allergic reaction, seek immediate medical attention.


CoAprovel is contraindicated in patients with hypersensitivity to either of its components, severe liver or kidney impairment, or difficult-to-treat low potassium levels. It should not be used during pregnancy due to potential fetal harm. Patients with a history of angioedema should use this medication with caution.


CoAprovel may interact with other medications, including other blood pressure medications, potassium supplements, lithium, and certain pain relievers. Always inform your healthcare provider about all medications and supplements you’re taking to avoid potential interactions.

Important Information

Regular blood pressure monitoring is essential while taking CoAprovel. Maintain a healthy lifestyle, including a balanced diet and regular exercise, to support the medication’s effectiveness. If you miss a dose, take it as soon as you remember, unless it’s almost time for your next dose. Never take a double dose to make up for a missed one.

Doses higher than 300 mg irbesartan/25 mg hydrochlorothiazide once daily are not recommended. The recommended dose of CoAprovel is one tablet a day. CoAprovel will usually be prescribed by your doctor when your previous treatment did not reduce your blood pressure enough. Your doctor will instruct you how to switch from the previous treatment to CoAprovel.


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