Dony Dovas 5mg Amlodipine Tablet X28

Dony Dovas 5mg Amlodipine Tablet is a prescription medication containing amlodipine, a calcium channel blocker used to manage hypertension (high blood pressure) and certain cardiovascular conditions. This tablet is designed to provide effective and long-lasting blood pressure control, reducing the risk of complications associated with uncontrolled hypertension.

Uses

Dovas 5mg Tablet (Amlodipine) is primarily used to treat:

• Hypertension (high blood pressure) as monotherapy or in combination with other antihypertensives
• Chronic stable angina pectoris (chest pain due to reduced heart blood flow)
• Vasospastic (Prinzmetal’s) angina
• Confirmed or suspected coronary artery disease
• Prevention of cardiovascular events in patients with coronary risk factors
• Peripheral vascular disease with claudication symptoms

Benefits

• Provides effective 24-hour blood pressure control with once-daily dosing
• Reduces frequency and severity of angina attacks
• Decreases risk of cardiovascular events including heart attack and stroke
• Demonstrates minimal impact on heart rate compared to other antihypertensives
• Shows beneficial effects on kidney function in hypertensive patients
• Maintains efficacy regardless of age, gender, or ethnicity
• Features excellent tolerance profile compared to other antihypertensive classes
• Offers flexible administration with or without food
• Demonstrates minimal drug interactions for safer use in patients on multiple medications
• Provides gradual onset of action reducing risk of first-dose hypotension

How It Works

Dovas 5mg works by selectively blocking L-type calcium channels in vascular smooth muscle and cardiac muscle cells. This action prevents calcium influx, leading to relaxation of arterial smooth muscle and reduced peripheral vascular resistance. Unlike some other calcium channel blockers, amlodipine has minimal effect on cardiac conduction or contractility at therapeutic doses. The medication’s long half-life allows for sustained blood pressure control over 24 hours with once-daily dosing. Additionally, Dovas helps improve oxygen delivery to heart tissue in angina patients by dilating coronary arteries.

Duration of Action

Dovas 5mg provides exceptionally long-lasting effects due to amlodipine’s extended half-life of 30-50 hours. After oral administration, peak plasma concentrations are reached within 6-12 hours. Steady-state plasma levels are achieved after 7-8 days of consistent dosing. The medication maintains therapeutic blood pressure control throughout the 24-hour dosing interval, including during early morning hours when cardiovascular risk is highest. This extended duration of action provides protection even if a dose is occasionally missed.

Dosage

Take Dovas 5mg Tablet consistently at approximately the same time each day, with or without food. Dosage adjustments should be made at minimum 7-14 day intervals to allow assessment of full therapeutic effect.

Side Effects

Common side effects of Dovas 5mg include ankle swelling (peripheral edema), headache, dizziness, facial flushing, and fatigue. These effects are typically mild to moderate and often diminish with continued treatment. Less common effects may include palpitations, abdominal discomfort, nausea, and somnolence. Serious adverse reactions are rare but may include significant hypotension, worsening angina upon initiation, or allergic reactions. The peripheral edema associated with Dovas is dose-dependent and results from arteriolar dilation rather than fluid retention or heart failure.

Warning

Severe hypotension can occur in patients with severe aortic stenosis or cardiogenic shock. Abrupt withdrawal of Dovas 5mg may lead to rebound hypertension in some patients; gradual dose reduction is recommended when discontinuing therapy. Use caution in patients with severe hepatic impairment as the medication is extensively metabolized by the liver. Patients with heart failure should be stable before initiating therapy. Monitor for signs of worsening cardiac function, particularly in patients with severe coronary artery disease, as rarely, increased frequency or duration of angina may occur during initial treatment or dose increases.

Pregnancy and Breastfeeding

Dovas 5mg falls under FDA Pregnancy Category C. Animal studies have shown adverse effects on fetal development at high doses, but there are no adequate well-controlled studies in pregnant women. Use during pregnancy only when potential benefits justify potential risks to the fetus. Alternative antihypertensives with better-established safety profiles during pregnancy should be considered when possible. Amlodipine is excreted in human milk. The effect on nursing infants is unknown, but caution is advised. Discuss risks and benefits with your healthcare provider if you are pregnant, planning pregnancy, or breastfeeding.

Interaction

• May increase serum levels of simvastatin and other statins metabolized by CYP3A4
• CYP3A4 inhibitors (ketoconazole, itraconazole) may increase amlodipine levels
• Grapefruit juice may increase drug bioavailability and enhance effects
• May enhance hypotensive effects when used with other antihypertensives
• NSAIDs may reduce antihypertensive efficacy
• Sildenafil and other PDE-5 inhibitors may cause additive blood pressure lowering

Precaution

Take Dovas 5mg with caution if you have liver disease, as clearance may be reduced requiring lower dosing. Elderly patients may be more sensitive to effects and typically require lower initial doses. Those with heart failure should be clinically stable before starting therapy. Monitor renal function in patients with severe renal impairment. The medication may mask symptoms of hyperthyroidism. Regular blood pressure monitoring is essential, especially when initiating therapy or adjusting dosage. Patients should be aware that postural hypotension may occur, particularly when combined with alcohol.

Important Information

Take Dovas 5mg at the same time each day to maintain consistent blood levels. Compliance is crucial for blood pressure control; missing doses may lead to blood pressure fluctuations. Blood pressure response may take 1-2 weeks to develop fully. Continue taking this medication even if you feel well, as hypertension is often asymptomatic. Do not stop taking Dovas abruptly without consulting your doctor. Lifestyle modifications including sodium restriction, weight management, and regular exercise enhance medication effectiveness.