Glucovance 1000mg/5mg is a dual-action antidiabetic medication combining metformin (1000mg) and glibenclamide (5mg). This prescription medication effectively manages type 2 diabetes through complementary mechanisms. It helps control blood sugar levels while improving insulin sensitivity.
Uses
Glucovance is specifically indicated for treating type 2 diabetes mellitus in adults, particularly when diet, exercise, and single-drug therapy don’t provide adequate glycemic control. It’s especially useful for patients requiring dual therapy for optimal diabetes management.
Benefits
- Provides dual mechanism for blood sugar control
- Improves insulin sensitivity
- Reduces hepatic glucose production
- Enhances glycemic control
- Convenient single-tablet combination
- Reduces need for multiple medications
- Helps achieve target HbA1c levels
- Cost-effective diabetes management
How It Works
Glucovance 1000mg/5mg combines two complementary mechanisms: Metformin reduces liver glucose production and improves insulin sensitivity, while Glibenclamide stimulates pancreatic insulin secretion and enhances glucose uptake by cells.
Dosage
| Patient Type | Dosage | Duration and Frequency |
|---|---|---|
| Initial Therapy | 1 tablet | Once daily with evening meal |
| Maintenance | 1-2 tablets | Twice daily with meals |
| Maximum Dose | 2 tablets | Twice daily, not to exceed |
Duration of Action
Effects begin within 24 hours of first dose. Optimal glycemic control typically achieved within 1-2 weeks. Full therapeutic effect may take up to 4 weeks. Blood sugar-lowering effect lasts 24 hours with proper dosing.
Side Effects
Common side effects of Glucovance 1000mg/5mg include gastrointestinal disturbances, metallic taste, mild nausea, and diarrhea. Serious side effects may include lactic acidosis (rare but serious) and hypoglycemia. Initial side effects often improve with continued use.
Warning
Seek immediate medical attention if experiencing signs of lactic acidosis (severe fatigue, muscle pain, difficulty breathing, stomach pain) or severe hypoglycemia. Regular monitoring of kidney and liver function is essential.
Pregnancy and Breastfeeding
Not recommended during pregnancy; insulin is the preferred treatment for diabetes during pregnancy. Should be avoided during breastfeeding due to potential risks to the infant.
Interactions
- Alcohol may increase risk of lactic acidosis
- NSAIDs may affect kidney function
- Beta-blockers may mask hypoglycemia symptoms
- Corticosteroids may increase blood glucose
- ACE inhibitors may enhance hypoglycemic effect
Precautions
Take with meals to minimize gastrointestinal effects. Regular blood glucose monitoring is essential. Avoid alcohol consumption. Maintain proper hydration. Exercise regularly and follow recommended diet plan. Carry glucose tablets or quick-acting sugar for hypoglycemia management.
Important Information
Glucovance should be part of a complete diabetes management program including diet, exercise, and regular blood sugar monitoring. Regular HbA1c testing is essential. Never skip meals when taking Glucovance. Store at room temperature away from moisture and heat.
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