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Libre Tablet 2mg ( Tizanidine)

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Libre Tablet 2mg contains tizanidine, a powerful muscle relaxant. it used to provide effective relief from muscle spasms, cramps, and stiffness


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Libre Tablet 2mg is a prescription medication containing tizanidine, a powerful muscle relaxant. This innovative tablet is designed to provide effective relief from muscle spasms, cramps, and stiffness, ultimately improving mobility and quality of life for patients.


Libre Tablet 2mg is an effective treatment option for:

  • Muscle spasticity associated with conditions such as multiple sclerosis, spinal cord injury, or cerebral palsy
  • Acute back pain and muscle spasms
  • Musculoskeletal conditions involving muscle tightness and discomfort

By reducing muscle spasms and promoting relaxation, Libre Tablet 2mg can help alleviate pain, improve flexibility, and enhance overall physical function for patients.

Side Effects

Like any medication, Libre Tablet 2mg may cause side effects. Common side effects may include:

  • Drowsiness or sedation
  • Dizziness
  • Dry mouth
  • Fatigue
  • Muscle weakness

Rare but serious side effects may include liver dysfunction, low blood pressure, and allergic reactions. Patients should report any concerning symptoms to their healthcare provider immediately.


  • Potent muscle relaxant for effective spasticity management
  • Improves mobility and flexibility
  • Enhances overall quality of life
  • Generally well-tolerated with a manageable side effect profile

Libre Tablet 2mg offers a reliable and effective solution for patients seeking relief from muscle spasms and spasticity, helping them regain independence and engage in daily activities more comfortably.

Mechanism of Action

Tizanidine, the active ingredient in Libre Tablet 2mg, works by modulating the activity of alpha-2 adrenergic receptors in the central nervous system. This action inhibits the release of excitatory neurotransmitters, leading to a reduction in muscle tone and spasticity, ultimately promoting muscle relaxation.

Dosage and Administration

Relief of painful muscle spasms: The usual dose is 2 to 4 mg three times daily in tablet form. In severe cases, an extra dose of 2 or 4 mg may be taken, preferably at night to minimize sedation.
Spasticity due to neurological disorders: The initial daily dose should not exceed 6 mg given in 3 divided doses. It may be increased stepwise at half-weekly or weekly intervals by 2 to 4 mg. The optimum therapeutic response is generally achieved with a daily dose of between 12 and 24 mg, administered in 3 or 4 equally spaced doses. The daily dose of 36 mg should not be exceeded.
Special populations: Pediatrics patients: Experience in patients below 18 years of age is limited and the use of tizanidine (Libre) in this population is not recommended.
Geriatrics patients (65 years of age or older): Experience with the use in the elderly is limited. Therefore, it is recommended to start treatment at the lowest dose and increases should be done in small steps according to tolerability and efficacy.

Libre Tablet 2mg should be taken as prescribed by a healthcare professional. The dosage may vary depending on the individual’s age, weight, and the severity of the condition being treated. It is essential to follow the prescribed instructions carefully for optimal results and to minimize potential side effects.

Important Information

Libre Tablet 2mg should be taken as directed, and patients should report any signs of adverse reactions or allergic responses to their healthcare provider immediately. Timely and effective management of muscle spasticity is crucial for improving mobility, reducing discomfort, and enhancing overall quality of life.

Initial dose: 2 mg orally every 6 to 8 hours as needed
  • Peak effects occur in approximately 1 to 2 hours and last for 3 to 6 hours; treatment can be repeated as needed to a maximum of 3 doses in 24 hours; gradually increase dose by 2 to 4 mg at intervals of 1 to 4 days until satisfactory reduction of muscle tone is achieved.
Maximum single dose: 16 mg Maximum daily dose: 36 mg in 24 hours Comments:
  • Clinically significant differences in absorption are expected between capsules and tablets when taken with or without food; these differences could result in changes in efficacy and tolerability.
  • Once a formulation is decided on and a decision is made to take with or without food, this regimen should not be altered.
Use: Management of spasticity.

Renal Dose Adjustments

Severe renal impairment (CrCl less than 25 mL/min): Individualize therapy with lower doses during dose titration; if higher doses are required, individual doses should be increased rather increasing the dosing frequency; closely monitor for toxicity

Liver Dose Adjustments

Not recommended

Dose Adjustments

Use with caution in elderly patients, especially those with renal impairment. Drug withdrawal:
  • Decrease by 2 to 4 mg per day, especially in patients who have been receiving doses of 20 to 36 mg per day for periods of 9 weeks or more.


Safety and efficacy have not been established in patients younger than 18 years. Consult WARNINGS section for additional precautions.


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