Mectizan, containing the active ingredient ivermectin, is an anti-parasitic medication used to treat several neglected tropical diseases. It is a semisynthetic derivative of a family of compounds produced by the soil bacterium Streptomyces avermitilis.
Uses
The main uses of Mectizan include:
- Treatment of onchocerciasis (river blindness)
- Treatment of strongyloidiasis
- Treatment of scabies
- Control programs to eliminate lymphatic filariasis
- Potential role in treating other parasitic worm infections
Benefits
Key benefits of taking Mectizan include:
- Effectively treats and prevents onchocerciasis, a leading cause of preventable blindness
- Rapidly eliminates scabies infestation
- Broad-spectrum anti-parasitic activity against several worm infections
- Well-tolerated with minimal adverse effects when used properly
Mechanism of Action
Ivermectin binds to and activates chloride channels in nerve and muscle cells of parasites, causing paralysis and death of the organism. It appears to have a higher affinity for invertebrate rather than vertebrate receptor channels.
Dosage
For onchocerciasis: 150-200 mcg/kg as a single oral dose, repeated annually
For strongyloidiasis: 200 mcg/kg once, repeated in 2 weeks
For scabies: 200 mcg/kg as a single oral dose Dosing may vary based on weight, severity, and physician guidance.
Side Effects
Most people tolerate ivermectin well. Potential side effects include headache, dizziness, muscle aches, nausea, and diarrhea. Rare serious reactions like neurological effects may occur in some with high parasite burden.
Warnings
Use with caution in those with liver disease or weighing less than 15kg. Avoid use in children under 5, or pregnant/breastfeeding women unless the benefits outweigh risks.
Important Information
Take Mectizan on an empty stomach with water for optimal absorption. Complete any prescribed re-treatment regimen. Do not share or save leftover medication. Immediately report any potential side effects to your doctor.
It is worth noting that there has been some controversy around the use of Mectizan for COVID-19 treatment, as some people have claimed that it can be effective in treating the disease.
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