Motilium 10mg tablets contain domperidone, a dopamine antagonist that effectively enhances upper gastrointestinal motility and reduces feelings of nausea and vomiting. This medication provides relief from various gastrointestinal symptoms while improving digestive function.
Uses
Motilium 10mg is primarily used for prevention and relief of nausea and vomiting. It helps in the management of bloating and upper abdominal discomfort. The medication is effective in treating gastroesophageal reflux disease (GERD). It provides relief from symptoms of functional dyspepsia and helps in the management of delayed gastric emptying.
Benefits
- Rapid relief from nausea and vomiting
- Improves upper gastrointestinal motility
- Reduces acid reflux symptoms
- Alleviates bloating and abdominal discomfort
- Enhances digestion efficiency
- May improve medication absorption in diabetic gastroparesis
- Helps restore normal digestive rhythm
- Promotes better nutrient absorption
- Reduces post-meal discomfort
How It Works
Domperidone acts as a peripheral dopamine D2 receptor antagonist, blocking dopamine receptors in the gastrointestinal tract. This action enhances acetylcholine release, which promotes increased gastric emptying and enhanced esophageal peristalsis. It also improves lower esophageal sphincter tone and better coordination of gastrointestinal motility.
Duration of Action
The onset of action typically occurs within 30-60 minutes after oral administration. The effects usually last for 4-6 hours, which supports the three-times-daily dosing regimen.
Dosage
The recommended dosage for adults and adolescents is one 10mg tablet taken up to three times daily. It should be taken 15-30 minutes before meals and if needed at bedtime. The maximum daily dose should not exceed 30mg. Treatment duration should not exceed one week without medical supervision.
Side Effects
Common side effects may include dry mouth, headache, mild stomach cramps, and dizziness. Some patients may experience changes in menstrual periods. Rare but serious side effects can include irregular heartbeat, muscle spasms, breast tenderness, and anxiety.
Warning
Motilium 10mg should be used with caution in patients with cardiac conditions and those taking medications that prolong QT interval. Special care is needed for individuals with liver or kidney disorders and patients over 60 years of age.
Pregnancy and Breastfeeding
Motilium should be used during pregnancy only if clearly needed and under medical supervision. While the drug is excreted in breast milk, it may be used during breastfeeding under medical guidance to promote lactation.
Interactions
- May interact with QT interval-prolonging medications
- Potential interactions with ketoconazole and other antifungal drugs
- Can interact with certain macrolide antibiotics
- May affect absorption of levothyroxine
- Known interactions with certain HIV medications
- Can interact with anticholinergic medications
- Possible interactions with certain antidepressants
- May affect the efficacy of oral contraceptives
- Interaction potential with certain anti-anxiety medications
Important Information
Complete the prescribed course even if symptoms improve. Take the medication at regular intervals as prescribed. Do not exceed the recommended daily dose. Seek immediate medical attention if experiencing irregular heartbeat, severe muscle spasms, or signs of allergic reaction. Store at room temperature away from moisture and light. Keep out of reach of children.
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