Osivir Infusion 500mg (Aciclovir) x1 Vial

Osivir Infusion 500mg is a potent antiviral medication delivered via intravenous infusion. Each single-dose vial contains 500mg of Aciclovir, specifically formulated for serious viral infections requiring immediate and direct administration into the bloodstream.

Uses

Osivir Infusion 500mg is indicated for severe herpes simplex infections, initial and recurrent genital herpes in immunocompromised patients, herpes simplex encephalitis, severe initial genital herpes, herpes zoster infections in immunocompromised patients, and varicella (chickenpox) infections in immunocompromised patients.

Benefits

• Rapid delivery of medication directly to bloodstream
• Effective against severe viral infections
• Appropriate when oral therapy isn’t suitable
• Provides treatment option for immunocompromised patients
• Helps prevent viral replication and spread
• Reduces duration and severity of symptoms
• Decreases risk of complications from severe infections
• Effective for CNS herpes infections

How It Works

Osivir Infusion 500mg contains Aciclovir, which is converted to aciclovir triphosphate inside virus-infected cells. This active form inhibits viral DNA polymerase, preventing viral DNA synthesis and replication, thereby stopping the spread of infection while allowing the immune system to clear infected cells.

Duration of Action

Intravenous Aciclovir reaches peak plasma concentrations immediately after infusion. The elimination half-life is approximately 2-3 hours in patients with normal renal function, with antiviral activity continuing for 4-8 hours after administration.

Dosage

Warnings

Osivir Infusion 500mg must be administered by slow intravenous infusion over at least 1 hour to avoid renal tubular damage. Rapid or bolus injection must be avoided. Adequate hydration is essential during treatment. Renal function should be monitored before and during therapy.

Side Effects

Common side effects include phlebitis or inflammation at the injection site, transient increases in liver enzymes, and reversible increases in blood urea and creatinine. Less common effects include nausea, vomiting, headache, skin rashes, and rarely, neurological reactions such as tremors or confusion.

Pregnancy and Breastfeeding

Osivir Infusion 500mg should be used during pregnancy only when the potential benefits outweigh possible risks to the fetus. Use during breastfeeding requires careful consideration as Aciclovir passes into breast milk in small amounts.

Interactions

• Nephrotoxic drugs (increased risk of renal impairment)
• Probenecid (decreased Aciclovir elimination)
• Mycophenolate mofetil (increased levels of both drugs)
• Theophylline (potential increased theophylline levels)
• Zidovudine (increased risk of neurological adverse effects)
• Cimetidine (increased Aciclovir plasma levels)

Precautions

For intravenous use only. Reconstitute and dilute according to instructions before administration. Administer by slow intravenous infusion only. Maintain adequate hydration. Monitor renal function. Discontinue immediately if signs of hypersensitivity occur. Dispose of unused portion of the single-dose vial.

Important Information

Osivir Infusion 500mg is for hospital use only. Administration should be supervised by healthcare professionals experienced in the use of antiviral therapy. The solution should be freshly prepared and used within 12 hours. This medication should be part of a comprehensive treatment approach for severe viral infections.