Resthrotec 75mg tablets contain a combination of diclofenac sodium 75mg (a nonsteroidal anti-inflammatory drug) and misoprostol 200mcg (a gastrointestinal mucosal protective prostaglandin E1 analog).
Uses
Resthrotec 75mg is used for reducing the risk of NSAID-induced gastric ulcers in patients at risk who require diclofenac therapy.
Benefits
Resthrotec 75mg offers dual benefits:
- Diclofenac for relief of pain and inflammation
- Misoprostol to decrease the chance of developing NSAID-induced gastric ulcers
Mechanism of Action
- Diclofenac inhibits COX enzymes leading to decreased prostaglandin synthesis resulting in anti-inflammatory, analgesic, and antipyretic effects.
- Misoprostol enhances defenses of the gastric mucosal lining.
Together they provide effective pain relief with protection against NSAID-associated gastric ulcers.
Dosage
- Recommended dose: 1 tablet twice daily with food
- Swallow tablets whole – do not split, crush or chew
- Duration as directed by physician (usually 7-14 days)
Side Effects
Possible side effects include:
- Abdominal pain, diarrhea, dyspepsia
- Dizziness, headache
- Nausea, vomiting
- Flatulence, constipation
- Increased risk of uterine contractions in pregnancy
Warnings
- Increased risk of cardiovascular events with prolonged NSAID use
- Avoid use in late pregnancy due to risk of early labor and fetal adverse effects
- Contraindicated in patients hypersensitive to diclofenac or misoprostol
Important Information
- Take with food to reduce stomach upset
- Avoid use with other NSAIDs or salicylates
- Report any signs of ulceration, bleeding or perforation
- Use lowest effective dose for shortest time needed
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