Fidson Chloramphenicol is a broad-spectrum antibiotic medication used to treat serious bacterial infections. This prescription-only antibiotic is effective against various bacterial strains and is typically reserved for infections that haven’t responded to other antibiotics due to its potential for serious side effects.
Uses
Fidson Chloramphenicol is prescribed for severe bacterial infections, particularly when other antibiotics are ineffective or contraindicated. It’s specifically used for typhoid fever, systemic infections, meningitis, and certain resistant bacterial infections when safer alternatives cannot be used.
Benefits
- Treats severe bacterial infections effectively
- Active against wide range of bacteria
- Provides rapid therapeutic response
- Effective against typhoid fever
- Treats meningitis when indicated
- Works against resistant organisms
- Penetrates cerebrospinal fluid well
- Cost-effective treatment option
How It Works
Chloramphenicol works by inhibiting bacterial protein synthesis by binding to the 50S subunit of bacterial ribosomes. This mechanism prevents bacteria from producing essential proteins needed for their growth and survival, ultimately leading to bacterial death.
Duration of Action
The medication begins working within 2-3 hours of administration. Full therapeutic effect is typically seen within 48-72 hours. Treatment duration usually ranges from 7-14 days, depending on infection type and severity.
Dosage
Adults: 500mg every 6 hours Severe infections: 1g every 6 hours Children: Based on body weight (50-100mg/kg/day divided into 4 doses) Complete prescribed course even if symptoms improve
Side Effects
Common side effects include nausea, diarrhea, and altered taste. More serious side effects can include bone marrow suppression, gray baby syndrome in newborns, and aplastic anemia. Regular blood monitoring is essential during treatment.
Warning
Requires regular blood count monitoring. Discontinue immediately if signs of bone marrow suppression occur. Not recommended as first-line treatment due to risk of serious side effects. Only use when benefits clearly outweigh risks.
Pregnancy and Breastfeeding
Not recommended during pregnancy or breastfeeding due to risk of gray baby syndrome and potential bone marrow toxicity. Contraindicated in late pregnancy and during labor. Alternative antibiotics should be considered.
Interactions
- May interact with iron supplements
- Reduces effectiveness of oral contraceptives
- Interacts with certain antidiabetic medications
- Affects anticoagulant medications
- May interact with other bone marrow suppressants
Important Information
Store below 25°C in a dry place. Complete full course of treatment. Regular blood tests required during therapy. Report any unusual bleeding, bruising, or signs of infection immediately. Not for use in mild infections. Keep medical appointments for monitoring. Don’t share this medication with others. Maintain adequate hydration during treatment. Avoid alcohol consumption.
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