Lokmal Suspension is a specialized pediatric antimalarial medication combining artemether and lumefantrine in a palatable fruit-flavored suspension. This child-friendly formulation ensures accurate dosing and enhanced compliance for treating uncomplicated malaria in children weighing under 35 kg.
Uses
Lokmal Suspension effectively treats acute, uncomplicated malaria caused by Plasmodium falciparum in infants and young children. It’s specifically designed for pediatric patients who require precise dosing and easy administration.
Benefits
- Provides rapid clearance of malaria parasites
- Offers child-friendly fruit flavor for better acceptance
- Ensures precise dosing through suspension form
- Demonstrates effectiveness against resistant strains
- Reduces risk of treatment failure
- Improves treatment compliance in children
- Features convenient twice-daily dosing
- Maintains stable potency throughout treatment
How It Works
The dual-action mechanism combines artemether’s rapid parasite elimination with lumefantrine’s extended antimalarial activity. Artemether quickly reduces the parasite burden, while lumefantrine prevents parasite replication in red blood cells, ensuring complete clearance.
Duration of Action
Initial parasite reduction occurs within 24 hours. The complete therapeutic effect develops over the 3-day treatment course, with protection extending up to 4 weeks post-treatment.
Dosage
| Weight Range (kg) | Suspension Amount | Frequency |
|---|---|---|
| 5-14 | 5mL (1 spoonful) | Twice daily |
| 15-24 | 10mL (2 spoonfuls) | Twice daily |
| 25-34 | 15mL (3 spoonfuls) | Twice daily |
Side Effects
Common effects include mild fever, headache, and gastrointestinal disturbances. Most side effects are temporary and resolve during treatment. Monitor children closely for any unusual reactions.
Warning
Not suitable for severe malaria cases requiring hospitalization. Use with caution in children with liver or kidney conditions. Seek immediate medical attention if symptoms worsen during treatment.
Pregnancy and Breastfeeding
Not applicable for the intended pediatric population. Nursing mothers should consult healthcare providers regarding potential risks to breastfed infants.
Interactions
- May interact with certain antibiotic medications
- Potential interactions with antifungal drugs
- Could affect heart rhythm medications
- May interact with some anticonvulsants
Precautions
Administer with fatty meals or milk to enhance absorption. Monitor child’s response throughout treatment. Ensure proper hydration during therapy.
Important Information
Lokmal Suspension requires consistent timing of doses and completion of the full three-day course. Shake well before each use to ensure proper drug distribution. Store below 25°C in the original container, protected from light. Always verify the child’s weight before administering. Monitor temperature and symptoms during treatment. If fever persists beyond 48 hours of treatment initiation, consult healthcare provider immediately. Keep detailed records of administration times and any observed side effects. Discard any remaining suspension after completing the prescribed course.
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