Rhoclone/RhoGAM Injection 300mcg x2ml

Rhoclone/RhoGAM Injection 300mcg contains Anti Rho-D Immunoglobulin (Monoclonal) as a freeze-dried preparation for intramuscular injection only. This medication prevents Rh sensitization in Rh-negative mothers carrying Rh-positive babies or following blood transfusion incompatibilities.

Uses

Rhoclone prevents hemolytic disease of the newborn by preventing Rh sensitization in Rh-negative women. It’s administered during pregnancy, after delivery, miscarriage, abortion, amniocentesis, or other procedures that may cause maternal-fetal blood mixing. Rhoclone also treats Rh-incompatible blood transfusion reactions.

Benefits

• Prevents maternal Rh sensitization effectively
• Protects future pregnancies from hemolytic disease
• Reduces risk of fetal anemia and hydrops fetalis
• Prevents need for intrauterine transfusions
• Eliminates risk of severe neonatal complications
• Provides passive immunity for immediate protection
• Safe for both mother and baby when used appropriately
• Long-established safety profile in pregnancy
• Prevents costly and complex fetal interventions

How It Works

Rhoclone contains antibodies that bind to Rh-positive fetal red blood cells that enter maternal circulation, preventing the mother’s immune system from recognizing them as foreign. This prevents formation of maternal anti-Rh antibodies that could attack Rh-positive babies in future pregnancies.

Dosage

Must be reconstituted with sterile water before injection. Administer deep intramuscular injection, preferably in deltoid muscle.

Duration of Action

Rhoclone provides immediate passive immunity lasting approximately 12 weeks. The antibodies circulate in maternal blood, neutralizing any Rh-positive fetal cells present. Protection is temporary, requiring repeat doses for subsequent pregnancies or risk exposures.

Side Effects

Most patients tolerate Rhoclone well. Common side effects include mild pain, swelling, or redness at injection site. Some patients experience low-grade fever, headache, or fatigue. Serious allergic reactions are extremely rare but may include difficulty breathing or severe swelling.

Warning

For intramuscular injection only – never give intravenously as this can cause severe reactions. Rhoclone is only effective when given to Rh-negative individuals. It will not help if mother is already sensitized to Rh antigen. Must be given within 72 hours of exposure for maximum effectiveness.

Pregnancy and Breastfeeding

Rhoclone/RhoGAM Injection is specifically designed for use during pregnancy and poses no risk to the developing baby. It’s the standard of care for preventing Rh sensitization in pregnancy. Safe to use while breastfeeding as it does not pass into breast milk in significant amounts.

Interaction

• No significant drug interactions reported
• May interfere with live virus vaccines for 3 months after administration
• Does not interact with other immunoglobulins
• May cause false positive results in some blood tests
• Compatible with other pregnancy medications

Precaution

Confirm Rh-negative status before administration. Not effective in women already sensitized to Rh antigen. Use with caution in patients with IgA deficiency or previous severe allergic reactions. Ensure proper reconstitution and sterile injection technique to prevent contamination.

Important Information

Rhoclone/RhoGAM Injection must be stored refrigerated and reconstituted properly before use. The freeze-dried powder should be clear and colorless after reconstitution. Do not use if solution appears cloudy or contains particles. This medication is derived from human plasma and undergoes extensive safety testing. Keep vaccination records updated as it may affect certain immunization schedules.