Gostinex Tablet 0.5mg (Carbergoline) x8

Gostinex Tablet 0.5mg contains Cabergoline, a long-acting dopamine receptor agonist. This medication treats hyperprolactinemia, prolactin-secreting pituitary tumors, and associated reproductive disorders by effectively reducing elevated prolactin levels.

Uses

Gostinex treats conditions caused by excess prolactin hormone including pituitary prolactinomas, infertility, irregular menstruation, and unwanted breast milk production. It’s also used to prevent lactation after childbirth when medically necessary and as adjunct therapy in Parkinson’s disease.

Benefits

• Effectively reduces elevated prolactin levels
• Shrinks prolactin-secreting pituitary tumors
• Restores normal menstrual cycles and ovulation
• Improves fertility in men and women
• Eliminates galactorrhea (unwanted milk production)
• Reduces prolactinoma-related headaches
• Improves sexual function and libido
• Long-lasting effects requiring less frequent dosing
• Better tolerated than older dopamine agonists

How It Works

Gostinex stimulates dopamine D2 receptors in the anterior pituitary gland, directly inhibiting prolactin secretion. Its long half-life provides sustained dopaminergic activity, maintaining prolactin suppression for days. The medication also reduces prolactinoma size by decreasing tumor cell proliferation and inducing tumor shrinkage.

Dosage

Take Gostinex with food to minimize gastrointestinal side effects. Dosage adjustments based on prolactin levels and clinical response.

Duration of Action

Gostinex begins working within 3 hours of administration with peak effects at 2-3 hours. Due to its extended half-life of 63-69 hours, prolactin suppression lasts up to one week, allowing twice-weekly dosing. Maximum therapeutic benefits for tumor reduction occur after 3-6 months.

Side Effects

Common side effects include nausea, dizziness, headache, and constipation. Patients may experience fatigue, abdominal pain, or hot flashes. Less frequent effects include depression, drowsiness, or nasal congestion. Rare but serious effects include cardiac valve problems with prolonged high-dose therapy.

Warning

Long-term Gostinex use may cause cardiac valve fibrosis requiring regular echocardiographic monitoring. Sudden sleep attacks may occur without warning, particularly while driving. First-dose hypotension is possible. Impulse control disorders including gambling or hypersexuality may develop during treatment.

Pregnancy and Breastfeeding

Discontinue Gostinex once pregnancy is confirmed unless treating large prolactinomas threatening vision. The medication is contraindicated during breastfeeding as it suppresses milk production. Women should use reliable contraception during treatment and for one month after stopping.

Interaction

• Reduced effectiveness with dopamine antagonists like metoclopramide
• Enhanced effects when combined with other dopamine agonists
• May interact with antipsychotic medications
• Potential blood pressure changes with antihypertensive drugs
• Contraindicated with ergot alkaloids due to increased toxicity risk

Precaution

Monitor blood pressure regularly, especially during initial treatment. Use cautiously in patients with cardiovascular disease, severe liver impairment, or history of mental health disorders. Avoid abrupt discontinuation in patients with prolactinomas. Regular cardiac evaluation recommended for long-term users.

Important Information

Gostinex requires periodic monitoring of prolactin levels, liver function, and cardiac status. Report persistent cough, breathing difficulties, or unusual urges immediately. May cause drowsiness affecting ability to drive or operate machinery. Store at room temperature protected from light and moisture. Purchase only from licensed pharmacies to ensure authenticity.