Cozima 325mg Tablet (Cefixime & Clavulanic acid) x10

Cozima 325mg Tablet is a combination antibiotic containing Cefixime and Clavulanic Acid. This broad-spectrum antibiotic treats various bacterial infections by inhibiting bacterial cell wall synthesis while preventing antibiotic resistance through beta-lactamase inhibition.

Uses

Cozima 325mg Tablet treats bacterial infections of the respiratory tract, urinary tract, skin, soft tissues, and ear-nose-throat infections. It’s effective against pneumonia, bronchitis, sinusitis, otitis media, urinary tract infections, and skin infections caused by susceptible bacteria.

Benefits

• Provides broad-spectrum antibacterial coverage
• Overcomes beta-lactamase resistance mechanisms
• Effective against both gram-positive and gram-negative bacteria
• Reduces infection severity and duration
• Prevents complications from untreated bacterial infections
• Well-absorbed orally with good tissue penetration
• Single daily or twice daily dosing convenience
• Suitable for outpatient treatment
• Reduces hospitalization need for moderate infections

How It Works

Cefixime, a third-generation cephalosporin, disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins. Clavulanic acid inhibits beta-lactamase enzymes produced by resistant bacteria, protecting Cefixime from degradation and extending its antibacterial spectrum against resistant organisms.

Dosage

Take Cozima 325 with water, preferably after meals to reduce stomach irritation. Complete the full prescribed course even if symptoms improve.

Duration of Action

Cozima 325mg begins showing effects within 1-2 hours of administration. Peak blood levels occur within 2-4 hours. The antibiotic effect lasts 8-12 hours, allowing twice-daily dosing. Clinical improvement typically occurs within 48-72 hours of starting treatment.

Side Effects

Common side effects include mild gastrointestinal disturbances like nausea, diarrhea, or abdominal discomfort. Some patients may experience headache, dizziness, or skin rash. Rarely, severe allergic reactions or antibiotic-associated colitis may occur requiring immediate medical attention.

Warning

Do not use if allergic to penicillin’s or cephalosporins. Cozima 325mg may cause severe allergic reactions including anaphylaxis. Prolonged use may lead to superinfections with resistant organisms or Clostridium difficile-associated diarrhea. Discontinue immediately if severe diarrhea or allergic symptoms develop.

Pregnancy and Breastfeeding

Cozima 325mg is generally considered safe during pregnancy when benefits outweigh risks. Both components are classified as pregnancy category B. Small amounts pass into breast milk but are usually compatible with breastfeeding. Consult healthcare provider before use during pregnancy or nursing.

Interaction

• May reduce effectiveness of oral contraceptives
• Possible increased effects when used with certain diuretics
• May enhance anticoagulant effects of warfarin
• Potential interaction with probenecid increasing drug levels
• May give false-positive results in certain glucose tests
• Possible reduced absorption with antacids containing aluminum or magnesium

Precaution

Use with caution in patients with kidney impairment, liver disease, or history of gastrointestinal disorders. Monitor for signs of allergic reactions, especially in patients with penicillin allergies. Maintain adequate fluid intake. Avoid alcohol during treatment to prevent gastrointestinal irritation.

Important Information

Cozima 325mg is effective only against bacterial infections, not viral infections like common cold or flu. Complete the full prescribed course to prevent antibiotic resistance. Do not share with others or save leftover tablets. Store at room temperature away from moisture and heat. Consult doctor if symptoms worsen or no improvement occurs within 48-72 hours.