Flucamed Suspension contains the antifungal agent fluconazole in a palatable liquid form. This medication is specifically designed for children and adults who have difficulty swallowing tablets. It effectively treats various fungal infections including thrush, candidiasis, ringworm, and fungal nail infections.
Uses
Flucamed suspension is clinically indicated for treating oropharyngeal and esophageal candidiasis, cryptococcal infections, systemic candida infections, and coccidioidomycosis. Treatment decisions are based on fungal culture sensitivities and individual patient factors under proper medical supervision.
Benefits
- Potent triazole antifungal in palatable liquid form
- Readily absorbed with excellent tissue distribution
- Can be used for prophylaxis against fungal spread
- Once daily dosage regimen
- Fairly well-tolerated oral antifungal
How It Works
Fluconazole accumulates in fungal cell membranes, altering permeability and inhibiting enzyme systems vital for ergosterol synthesis. This mechanism effectively halts fungal growth by disrupting the integrity of the fungal cell membrane, preventing reproduction and spread of the infection.
Dosage
Age Group | Weight | Daily Dose (ml) | Treatment Duration |
---|---|---|---|
Neonates (0-14 days) | – | 0.5-1 ml | 7-14 days |
Infants (2 weeks-1 year) | – | 1-2 ml | 7-14 days |
Children (1-5 years) | 10-20 kg | 2-4 ml | 7-28 days |
Children (6-12 years) | 20-40 kg | 4-8 ml | 7-28 days |
Adolescents (12+ years) | >40 kg | 8-10 ml | 7-28 days |
Adults | >50 kg | 10 ml | 7-28 days |
Dose calculated at 3-7 mg/kg daily. Treatment duration depends on type and severity of infection. Always follow healthcare provider’s specific instructions.
Duration of Action
Flucamed begins working shortly after administration, with therapeutic levels reached within 2-4 hours. Clinical improvement typically begins within 24-72 hours of starting treatment. The medication maintains effective levels in tissues for 24 hours, allowing once-daily dosing. Complete fungal clearance requires full treatment course completion.
Side Effects
Common side effects include mild stomach upset, headache, and occasional dizziness. Less common effects include skin rash, altered taste sensation, and mild liver enzyme elevation. Most side effects are temporary and resolve without intervention during or after completing treatment.
Warning
Seek immediate medical care if signs of severe skin reaction (rash, blistering), jaundice (yellowing of skin/eyes), or liver issues (dark urine, persistent nausea, abdominal pain) occur. Requires close medical monitoring, especially for patients with pre-existing liver or kidney conditions.
Pregnancy and Breastfeeding
Flucamed should be used during pregnancy only when clearly needed and when potential benefits outweigh possible risks to the fetus. High-dose, long-term use should be avoided during pregnancy when possible. Fluconazole passes into breast milk. Consult healthcare provider before using while breastfeeding.
Interaction
- May increase effects of warfarin and other blood thinners
- Potential interaction with oral hypoglycemics causing hypoglycemia
- Can increase levels of certain statins, raising risk of muscle problems
- May affect levels of certain antiseizure medications
- Possible interaction with cyclosporine in transplant patients
Precaution
Use with caution in patients with liver or kidney impairment. Dosage adjustment may be necessary for these patients. Monitor for signs of liver toxicity, especially with prolonged treatment. Avoid alcohol consumption during treatment as it may increase risk of liver effects and decrease effectiveness.
Important Information
Inform your doctor about any liver or kidney issues before starting Flucamed. Follow prescription instructions carefully for proper completion of the antifungal regimen. Take at the same time each day to maintain consistent blood levels. Complete the entire prescribed course even if symptoms improve to prevent recurrence and resistance development.
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