Coartem 80mg/480mg Tablet x6

Coartem 80/480mg combines artemether and lumefantrine in a single tablet to effectively target malarial parasites. This powerful antimalarial medication provides comprehensive treatment for Plasmodium falciparum infections through its dual-action mechanism.

Uses

Coartem 80/480mg is specifically indicated for the treatment of uncomplicated malaria caused by Plasmodium falciparum in adults.

Benefits

• Combination therapy for rapid and complete elimination of malaria parasites
• Artemether provides rapid reduction in parasite load
• Lumefantrine eliminates remaining parasites, preventing recurrence
• Effective against drug-resistant strains of malaria
• Established efficacy in endemic regions
• Recommended by WHO for uncomplicated malaria treatment

How It Works

Coartem 80/480mg works through a dual mechanism of action. Artemether, a derivative of artemisinin, rapidly reduces the malaria parasite load through potent antimalarial activity. Lumefantrine, a long-acting antimalarial agent, eliminates any remaining parasites in the body, preventing recurrence of infection.

Duration of Action

Artemether begins working within hours of administration, with a short half-life of 2-3 hours. Lumefantrine provides extended antimalarial action with a half-life of 3-6 days, ensuring complete parasite elimination.

Dosage

Warnings

Not recommended for children under 35kg (77lbs); a specialized pediatric formulation is available. Not suitable for severe malaria or non-falciparum malaria infections which require different treatment protocols. Contraindicated in individuals with certain heart conditions or those taking specific medications.

Side Effects

May cause headache, dizziness, abdominal pain, loss of appetite, nausea, weakness, muscle and joint pain, and sleep disturbances. Most side effects are mild to moderate and resolve after treatment completion.

Pregnancy and Breastfeeding

Safety during pregnancy depends on malaria risk versus medication risk. First trimester use should be carefully evaluated. Limited data suggests lumefantrine exposure through breast milk is minimal, but healthcare provider consultation is essential.

Interactions

• QT-prolonging medications (increased cardiac risk)
• CYP3A4 inhibitors (increased drug levels)
• CYP3A4 inducers (decreased efficacy)
• Antiretroviral medications (potential interactions)
• Grapefruit juice (altered absorption)
• Anticoagulants (potential interaction)

Precautions

Take with fatty foods or milk to ensure proper absorption. Complete the full 3-day course even if symptoms improve. Report any signs of new infection, rash, or breathing problems immediately. Not for preventative use or prophylaxis.

Important Information

Coartem 80/480mg must be taken with fat-containing foods or milk for optimal absorption. Complete the full 3-day course, even if symptoms improve, to prevent recurrence. Follow up closely with your healthcare provider after treatment for monitoring and further care.