Lonart Suspension is an essential antimalarial medication used for the treatment of uncomplicated malaria caused by the Plasmodium falciparum parasite. This oral suspension combines two powerful active ingredients, artemether and lumefantrine, in a fixed-dose combination, providing a potent and effective solution for combating this life-threatening disease.
Uses
Lonart Suspension is indicated for the treatment of acute, uncomplicated malaria infections caused by Plasmodium falciparum in adults, children, and infants. It is particularly valuable in areas where resistance to conventional antimalarial drugs is a concern, as it acts through a unique mechanism of action, making it an indispensable tool in the global fight against malaria.
Benefits
- Provides rapid malaria parasite clearance
- Effective against drug-resistant Plasmodium strains
- Pediatric-friendly liquid formulation for easy administration
- Reduces fever and malaria symptoms quickly
- Prevents malaria recurrence with dual-action therapy
- Short 3-day treatment course improves compliance
- Well-tolerated in children and adults
- Demonstrates high cure rates across age groups
- Pleasant taste enhances patient acceptance
How It Works
Artemether rapidly kills blood-stage malaria parasites through free radical generation, providing quick symptom relief within hours. Lumefantrine has a longer half-life, eliminating remaining parasites and preventing recrudescence. This combination ensures complete parasite clearance and reduces resistance development.
Dosage
Category (Weight/Age) | Dosage Instructions | Total Daily Volume |
---|---|---|
5-14 kg (6 months-3 years) | 5ml twice daily for 3 days | 10ml daily |
15-24 kg (4-8 years) | 10ml twice daily for 3 days | 20ml daily |
25-34 kg (9-14 years) | 15ml twice daily for 3 days | 30ml daily |
≥35 kg (15 years+, adults) | 20ml twice daily for 3 days | 40ml daily |
Give doses 8 hours apart with food or milk to enhance absorption. Shake suspension well before each dose.
Duration of Action
Lonart Suspension begins working within 2-4 hours of the first dose. Artemether clears most parasites within 24-48 hours, while fever typically subsides within 48 hours. Lumefantrine provides protection against recurrence for 2-3 weeks due to its extended half-life.
Side Effects
Most patients tolerate Lonart Suspension well. Common side effects include mild headache, dizziness, nausea, and abdominal discomfort. Children may experience decreased appetite or sleep disturbances. These effects are usually mild and resolve without intervention as treatment progresses.
Warning
Complete the full 3-day course even if symptoms improve early. Do not use in patients with severe malaria requiring hospitalization. If vomiting occurs within 1 hour of dosing, repeat the dose. Seek immediate medical attention for persistent high fever, convulsions, or severe vomiting.
Pregnancy and Breastfeeding
Lonart Suspension is safe during the second and third trimesters when malaria poses significant maternal risk. Avoid during first trimester unless benefits clearly outweigh potential risks. The medication passes into breast milk in small amounts but is generally considered safe during breastfeeding.
Interaction
- May reduce effectiveness of hormonal contraceptives
- Possible interaction with anticonvulsant medications
- Could alter absorption when taken with antacids
- May interact with certain HIV medications
- Grapefruit juice may increase drug concentration levels
Precaution
Use with caution in patients with liver impairment or severe kidney disease. Store suspension at room temperature and use within prescribed timeframe after opening. Ensure accurate dosing using provided measuring device. Monitor for signs of treatment failure or recurring symptoms.
Important Information
Lonart Suspension does not prevent new malaria infections or transmission to others. Continue mosquito bite prevention measures during and after treatment. Shake bottle well before each use and measure doses accurately. If symptoms persist or worsen after completing treatment, consult healthcare provider immediately. Store in original container away from light and heat.
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