Trendate 200mg Tablet (Labetalol) x56

Trendate 200mg Tablet contains Labetalol, a combined alpha and beta-adrenergic receptor blocker. This antihypertensive medication effectively controls high blood pressure and manages hypertensive emergencies by blocking both alpha and beta receptors.

Uses

Trendate 200mg Tablet treats essential hypertension, pregnancy-induced hypertension, and hypertensive crises. It’s particularly effective for managing blood pressure in patients with diabetes, kidney disease, or those requiring rapid blood pressure control during emergencies.

Benefits

• Provides effective blood pressure reduction
• Combines alpha and beta-blocking actions
• Suitable for hypertensive emergencies
• Safe for use during pregnancy
• Reduces risk of stroke and heart attack
• Improves cardiovascular outcomes
• Can be used with other antihypertensive medications
• Maintains cardiac output better than pure beta-blockers
• Effective in diabetic patients

How It Works

Trendate blocks both alpha-1 and beta-adrenergic receptors. Alpha-blockade causes vasodilation reducing peripheral resistance, while beta-blockade decreases heart rate and cardiac contractility. This dual mechanism provides effective blood pressure reduction with less reflex tachycardia compared to pure alpha-blockers.

Dosage

Take Trendate with or without food at the same times daily. Dosage should be adjusted gradually based on blood pressure response.

Duration of Action

Trendate begins lowering blood pressure within 2-4 hours of oral administration. Peak effects occur at 2-4 hours and last 8-12 hours. In hypertensive emergencies, significant blood pressure reduction typically occurs within 1-2 hours. Regular dosing maintains consistent blood pressure control.

Side Effects

Common side effects include dizziness, fatigue, nausea, and headache. Some patients experience scalp tingling, nasal congestion, or digestive upset. Serious but rare effects include severe bradycardia, bronchospasm, or liver toxicity. Most side effects are dose-related and improve with continued use.

Warning

Do not stop Trendate abruptly as this may cause rebound hypertension or cardiovascular events. Use with caution in patients with asthma, COPD, or severe heart failure. Monitor liver function during long-term use. Seek immediate medical attention for difficulty breathing, severe dizziness, or chest pain.

Pregnancy and Breastfeeding

Trendate is considered safe during pregnancy and is often preferred for treating pregnancy-induced hypertension. It does not appear to harm the developing fetus. Small amounts pass into breast milk, but it’s generally considered safe for nursing mothers under medical supervision.

Interaction

• Enhanced hypotensive effects with other blood pressure medications
• May mask signs of hypoglycemia in diabetic patients
• Reduced effectiveness with NSAIDs or corticosteroids
• Potential for increased effects with cimetidine
• May alter effectiveness of insulin or diabetes medications
• Possible interaction with anesthetic agents during surgery

Precaution

Use cautiously in patients with liver disease, severe heart failure, or respiratory conditions. Regular monitoring of blood pressure, heart rate, and liver function is recommended. Avoid sudden position changes to prevent dizziness. Inform healthcare providers about Trendate use before any surgical procedures.

Important Information

Trendate requires regular medical supervision and blood pressure monitoring. Take doses at consistent times daily for optimal control. Keep a blood pressure log to share with your healthcare provider. Do not skip doses or stop medication without medical guidance. Store at room temperature away from moisture and heat.