Co-Amoxiclav Suspension 228.5mg is an antibiotic combination containing amoxicillin and clavulanic acid. This broad-spectrum formulation treats bacterial infections in pediatric and adult patients who have difficulty swallowing tablets, offering enhanced effectiveness against resistant bacteria.
Uses
Co-Amoxiclav Suspension treats respiratory tract infections (sinusitis, bronchitis, pneumonia), ear infections, urinary tract infections, typhoid fever, skin and soft tissue infections, and dental abscesses. It’s effective against many bacteria that have developed resistance to standard antibiotics through beta-lactamase production.
Benefits
- Provides broad-spectrum antibacterial activity
- Overcomes resistance with beta-lactamase inhibitor component
- Offers convenient liquid formulation for children and adults with swallowing difficulties
- Demonstrates high efficacy for common community-acquired infections
- Produces rapid clinical improvement in most cases
- Reduces risk of treatment failure
- Generally well-tolerated in pediatric populations
- Available as palatable suspension with improved compliance
How It Works
Amoxicillin binds to bacterial cell walls, preventing their formation and causing bacterial death. Clavulanic acid protects amoxicillin from degradation by beta-lactamase enzymes that resistant bacteria produce. This combination allows the antibiotic to overcome resistance mechanisms and effectively eliminate infection.
Dosage
| Age Group | Standard Dosage | Duration |
|---|---|---|
| 3-11 months | 2.5ml twice daily | 5-10 days |
| 1-5 years | 5ml twice daily | 5-10 days |
| 6-12 years | 10ml twice daily | 5-10 days |
Shake well before use. Administer using the measuring device provided. Take with meals to enhance absorption and reduce stomach upset.
Duration of Action
Co-Amoxiclav begins working within 1-2 hours after administration. Therapeutic blood levels are maintained when taken three times daily. Complete the full prescribed course (typically 5-10 days) even if symptoms improve after a few days to prevent recurrence and antibiotic resistance.
Side Effects
Common side effects include diarrhea, nausea, vomiting, and skin rash. Less common effects are candidiasis (thrush) and digestive discomfort. Rare but serious side effects include severe allergic reactions, prolonged diarrhea, and liver function abnormalities requiring immediate medical attention.
Warning
Allergic reactions can be serious or life-threatening. Discontinue use and seek emergency care for rash, itching, swelling, severe dizziness, or difficulty breathing. Watch for Clostridium difficile-associated diarrhea which may occur weeks after finishing treatment. Not for viral infections like cold or flu.
Pregnancy and Breastfeeding
Co-Amoxiclav is generally considered safe during pregnancy when benefits outweigh risks. It passes into breast milk in small amounts but is usually compatible with breastfeeding. Consult healthcare provider before use in either situation for individualized assessment.
Interaction
- May reduce effectiveness of oral contraceptives
- Potential increased risk of rash with allopurinol
- Possible interaction with anticoagulants, increasing bleeding risk
- May alter results of certain diagnostic tests
- Probenecid increases amoxicillin blood levels
Precaution
Use with caution in patients with penicillin allergies, as cross-reactivity may occur. Adjust dosage in patients with kidney impairment. Monitor liver function in extended therapy. Refrigerate suspension after reconstitution and discard after 7-10 days (check product-specific instructions). Verify proper dosage calculations for children.
Important Information
Complete the full prescribed course of Co-Amoxiclav Suspension, even if feeling better. Take at evenly spaced intervals to maintain consistent blood levels. Refrigerate after reconstitution and shake well before each use. Measure doses accurately using provided device. Report persistent symptoms or worsening condition to healthcare provider promptly.
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