Augmentin suspension 457mg/5mL is a potent, broad-spectrum antibiotic formulation specifically designed for infants and young children. This fruity-flavored oral suspension combines amoxicillin trihydrate and potassium clavulanate to effectively combat a wide range of bacterial infections, including those resistant to standard antibiotics.
Uses
Augmentin suspension 457mg/5mL is primarily prescribed for pediatric patients to treat ear infections (otitis media), tonsillitis, pneumonia, sinusitis, and other mild to moderate bacterial infections unresponsive to standard antibiotics. The addition of clavulanate potassium enhances the bactericidal efficacy of amoxicillin, making it effective against a broader range of bacteria, including some resistant strains.
Benefits
- Broad-spectrum antibiotic action against various bacterial infections
- Enhanced efficacy against resistant bacterial strains
- Specifically formulated for pediatric use
- Fruity flavor improves palatability for children
- Suspension form allows for precise, weight-based dosing
- Combines two active ingredients for improved bacterial killing
How It Works
Augmentin suspension 457mg/5mL works through a dual-action mechanism. Amoxicillin, a penicillin-type antibiotic, interferes with bacterial cell wall synthesis. Clavulanate potassium inhibits beta-lactamase enzymes produced by resistant bacteria. This combination allows the antibiotic to overcome resistance mechanisms, resulting in more effective bacterial killing and infection resolution.
Dosage
The dosage of Augmentin suspension 457mg/5mL is weight-based for pediatric patients. The typical dosing range is 25-90mg/kg/day, administered in divided doses every 12 hours (twice daily). Exact dosage should be determined by a healthcare professional based on the child’s weight and infection severity. Always complete the full prescribed course, even if symptoms improve earlier. Shake the bottle well before each use to ensure proper distribution of the active ingredients.
Side Effects
While generally well-tolerated, some patients may experience diarrhea, nausea or vomiting, candidiasis (yeast infection), or skin rash. If these effects persist or worsen, consult your healthcare provider promptly.
Warning
Seek immediate medical attention if you observe severe or persistent diarrhea, severe skin reactions or rash, swelling of face, lips, tongue, or throat, difficulty breathing, or lack of urine output. Augmentin suspension may cause false positive results on certain diabetic urine tests. Inform your healthcare provider if the child has diabetes.
Pregnancy and Breastfeeding
While this formulation is specifically for pediatric use, it’s important to note that Augmentin is generally considered safe during pregnancy and breastfeeding. However, always consult a healthcare provider for individual advice.
Interaction
- May reduce the effectiveness of oral contraceptives
- Potential interaction with allopurinol, increasing the risk of skin rash
- May interfere with certain blood tests
- Could increase the risk of bleeding when used with anticoagulants
- Possible interaction with probenecid, increasing amoxicillin levels in the blood
Important Information
Refrigerate the suspension after reconstitution. The reconstituted suspension remains stable for 10 days when refrigerated. Always check the expiration date and do not use if expired. Shake the bottle well before each use to ensure proper distribution of the medication. Do not use if the tamper-evident seal is broken or missing. This medication is specifically formulated for children, so proper dosing based on weight is crucial. Always use the measuring device provided with the medication for accurate dosing. Never use household spoons, as they can lead to dosing errors.
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