Crescents Simvastatin 20mg Tablet x28

Crescents Simvastatin 20mg is a potent statin medication designed to effectively manage cholesterol levels. This prescription drug contains simvastatin as its active ingredient, offering a reliable solution for patients requiring lipid control and cardiovascular risk reduction.

Uses

• Primary prevention of cardiovascular events in high-risk patients
• Secondary prevention in patients with coronary heart disease
• Treatment of primary hypercholesterolemia and mixed dyslipidemia
• Management of heterozygous familial hypercholesterolemia in pediatric patients
• Slowing the progression of atherosclerosis

Benefits

• Significantly reduces LDL (bad) cholesterol levels
• Moderately increases HDL (good) cholesterol
• Lowers triglyceride levels
• Decreases the risk of heart attack, stroke, and cardiovascular death
• Improves overall lipid profile
• Cost-effective treatment option for cholesterol management

How It Works

Simvastatin works by inhibiting HMG-CoA reductase, a key enzyme in cholesterol synthesis in the liver. This action leads to increased LDL receptor activity, enhancing the clearance of LDL cholesterol from the bloodstream. It also modestly increases HDL cholesterol and reduces triglycerides.

Dosage

The typical starting dose is 10-20mg once daily, taken in the evening. The 20mg strength is commonly used for maintenance therapy. Dosage may be adjusted based on lipid levels and treatment goals, with a maximum recommended dose of 40mg daily.

Side Effects

Common side effects may include muscle pain, headache, and gastrointestinal discomfort. Rare but serious side effects can include myopathy, rhabdomyolysis, and liver dysfunction. Regular monitoring of liver function and muscle symptoms is recommended.

Warning

Crescents Simvastatin 20mg should be used with caution in patients with a history of liver disease, heavy alcohol use, or those at risk for myopathy. It is contraindicated during pregnancy and lactation. Patients should report any unexplained muscle pain, tenderness, or weakness promptly to their healthcare provider.

Interaction

• Increased risk of myopathy with gemfibrozil and other fibrates
• Enhanced effect when combined with ezetimibe
• Potential interaction with strong CYP3A4 inhibitors (e.g., itraconazole, ketoconazole)
• Increased risk of myopathy when used with amiodarone or verapamil
• May increase the effect of warfarin, requiring close monitoring

Important Information

Crescents Simvastatin 20mg should be taken as part of a comprehensive approach to cholesterol management, including diet and exercise. Regular lipid profile monitoring is essential to assess efficacy and adjust treatment as needed. Grapefruit products should be avoided due to potential interactions.