Kwality Lamivudine 150mg Tablet x60

Kwality Lamivudine 150mg Tablet is an antiviral medication belonging to the nucleoside reverse transcriptase inhibitor (NRTI) class. This medication is primarily used in the treatment of HIV infection and chronic hepatitis B virus (HBV) infection.

Uses

Kwality Lamivudine 150mg treats HIV-1 infection as part of combination antiretroviral therapy. It’s also used to manage chronic hepatitis B in patients with evidence of active viral replication and liver inflammation. For both conditions, it’s typically prescribed as part of a comprehensive treatment regimen.

Benefits

• Reduces HIV viral load in the bloodstream
• Slows progression of HIV infection
• Improves immune function in HIV patients
• Decreases HBV viral replication
• Reduces liver inflammation in chronic hepatitis B
• Lowers risk of liver damage and complications
• Helps prevent mother-to-child HIV transmission
• Well-tolerated by most patients
• Available in convenient tablet form

How It Works

Lamivudine works by inhibiting the reverse transcriptase enzyme essential for viral replication. Once inside cells, it is converted to lamivudine triphosphate, which competes with natural nucleosides to be incorporated into viral DNA. This interrupts the viral replication process, preventing the virus from multiplying.

Dosage

Take Kwality Lamivudine with or without food at consistent times each day. Dosage may be adjusted for patients with renal impairment.

Duration of Action

Kwality Lamivudine begins working shortly after administration. The active metabolite has an intracellular half-life of 16-19 hours, allowing for once or twice-daily dosing. Antiviral effects continue as long as the medication is taken regularly, with viral load reductions typically observed within 4-8 weeks of treatment initiation.

Side Effects

Most patients tolerate Kwality Lamivudine well. Common side effects include headache, fatigue, nausea, diarrhea, and occasional sleep disturbances. Less common effects include mild abdominal pain and cough. Rare but serious side effects include lactic acidosis, severe hepatomegaly with steatosis, and pancreatitis.

Warning

Discontinue Kwality Lamivudine if clinical or laboratory findings suggest lactic acidosis or hepatotoxicity. Patients should be monitored for hepatitis exacerbation when stopping treatment. HIV resistance may develop if used as monotherapy; always use as part of combination therapy for HIV. HBV resistance may also develop with long-term use.

Pregnancy and Breastfeeding

Kwality Lamivudine can be used during pregnancy when benefits outweigh risks. It’s included in regimens to prevent mother-to-child HIV transmission. HIV-positive mothers should not breastfeed regardless of treatment to avoid transmission risk. For HBV-positive mothers, decisions about breastfeeding should be made in consultation with healthcare providers.

Interaction

• May increase risk of pancreatitis with other pancreatotoxic drugs
• Potential for decreased effectiveness with co-administered sorbitol
• Possible interaction with emtricitabine due to similar mechanisms
• Trimethoprim-sulfamethoxazole may increase lamivudine levels
• No significant interactions with most other medications

Precaution

Use with caution in patients with renal impairment; dose adjustment may be required. Monitor liver function in patients with hepatitis B, especially when discontinuing treatment. Children with history of pancreatitis require close monitoring. Regular assessment of kidney function is recommended during long-term therapy.

Important Information

Kwality Lamivudine does not cure HIV or hepatitis B but helps control viral replication. Strict adherence to the dosing schedule is essential for effectiveness and to prevent resistance. Missing doses increases the risk of treatment failure. Patients should be regularly monitored for viral load, immune function, and liver enzymes. Continue practicing safe behaviors to prevent transmission to others.