Milpharm Lamotrigine 25mg Tablet x56

Milpharm Lamotrigine 25mg Tablet is an anticonvulsant medication used to treat epilepsy and bipolar disorder. This low-dose formulation is often used as a starting dose or for maintenance therapy when precise dosing is required.

Uses

Milpharm Lamotrigine treats various types of seizures in epilepsy, including partial seizures, primary generalized tonic-clonic seizures, and Lennox-Gastaut syndrome. It’s also used to prevent mood episodes in bipolar disorder, particularly depression phases. The 25mg strength is commonly used for initial therapy or pediatric dosing.

Benefits

• Controls seizures in various forms of epilepsy
• Prevents mood episodes in bipolar disorder
• Provides a longer seizure-free period
• Reduces frequency and severity of seizures
• Stabilizes mood in bipolar patients
• Improves quality of life with manageable side effects
• Often effective when other medications have failed
• Suitable for combination therapy in resistant cases
• Available in convenient tablet form

How It Works

Lamotrigine works by stabilizing neuronal membranes and inhibiting the release of excitatory neurotransmitters, particularly glutamate. By reducing excess electrical activity in the brain, it prevents seizures and stabilizes mood fluctuations. Unlike many mood stabilizers, it’s particularly effective for the depressive phase of bipolar disorder.

Dosage

Dosage must be gradually increased. Follow physician instructions exactly, as rapid dosage increases risk serious side effects.

Duration of Action

Milpharm Lamotrigine reaches steady blood levels within 4-5 days of consistent dosing. The half-life averages 24-35 hours in adults. Full therapeutic benefits for epilepsy may require several weeks of treatment. For bipolar disorder, mood stabilization may take 4-6 weeks to achieve optimal effect.

Side Effects

Common side effects include headache, dizziness, blurred vision, double vision, nausea, and drowsiness. Most side effects are mild and diminish over time. A serious skin rash requiring immediate medical attention occurs in approximately 0.3-1% of patients, particularly within the first 8 weeks of treatment.

Warning

Serious, potentially life-threatening skin rashes (including Stevens-Johnson syndrome) may occur, especially during the first 8 weeks. Discontinue immediately and seek medical help for any rash. Risk increases with rapid dose escalation, concurrent valproate use, and in pediatric patients. Monitor for signs of suicidal thoughts, unusual behavior changes, or worsening depression.

Pregnancy and Breastfeeding

Milpharm Lamotrigine crosses the placenta and presents possible risks to the developing fetus, including potential increased risk of oral clefts if taken during first trimester. However, untreated seizures pose significant risks to both mother and fetus. Lamotrigine passes into breast milk. Discuss risks and benefits with your healthcare provider.

Interaction

• Increases blood levels when taken with valproate
• Decreased levels when taken with carbamazepine, phenytoin, or phenobarbital
• May reduce effectiveness of hormonal contraceptives
• Potential interaction with other anticonvulsants
• Interaction possible with certain antidepressants
• May affect or be affected by certain antibiotics

Precaution

Withdraw medication gradually to prevent seizure rebound. Use caution in patients with kidney or liver impairment, cardiac conduction disorders, or history of allergic reactions to medications. Be alert for mood changes, depression, or suicidal thoughts. Regular follow-up with healthcare provider is essential to monitor response and adjust dosage.

Important Information

Milpharm Lamotrigine 25mg is a prescription-only medication requiring medical supervision. Never suddenly stop taking this medication. Take at the same time each day. Avoid alcohol as it may increase side effects. Keep all follow-up appointments and laboratory tests. Store at room temperature away from moisture and light.