Eppilion Chrono 500mg (Sodium Valproate) x100
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Eppilion Chrono 500mg is used for the treatment of various forms of epilepsy in both adults and children and management of bipolar disorder
₦75,000.00
Buy NowEppilion Chrono 500mg is an extended-release formulation of sodium valproate, a potent anticonvulsant medication. This chrono formulation provides sustained release of the active ingredient, offering prolonged seizure control with convenient once-daily dosing for patients with epilepsy.
Uses
Eppilion Chrono 500mg is primarily used for:
- Treatment of various forms of epilepsy
- Management of bipolar disorder
- Prevention of migraine headaches
Benefits
- Provides extended seizure control
- Reduces frequency and severity of epileptic seizures
- Convenient once-daily dosing
- Improves compliance due to simplified dosing regimen
- Stabilizes mood in bipolar disorder
- May decrease the frequency of migraine attacks
How It Works
Sodium valproate enhances the activity of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits excessive neuronal firing in the brain. This action helps prevent and control seizures. The chrono formulation ensures a steady release of the medication over 24 hours, maintaining therapeutic levels in the body.
Duration of Action
Eppilion Chrono 500mg provides a sustained release of sodium valproate over 24 hours. This extended-release formulation maintains therapeutic levels in the blood throughout the day, offering consistent seizure protection and reducing the risk of breakthrough seizures.
Dosage
The dosage of Eppilion Chrono 500mg is individualized based on the patient’s condition, weight, and response to treatment. Typically, the starting dose for adults is 500mg once daily, which may be increased gradually as needed. The maximum recommended daily dose is usually 2500mg. Always follow your healthcare provider’s instructions regarding dosage.
Side Effects
Common side effects may include nausea, vomiting, dizziness, and drowsiness. More serious side effects can include liver dysfunction, pancreatitis, and blood disorders. If you experience any severe or persistent side effects, contact your healthcare provider immediately.
Warning
Eppilion Chrono 500mg should be used with caution in patients with liver disease, blood disorders, or a history of pancreatitis. Regular blood tests may be required to monitor liver function and blood cell counts. This medication may cause birth defects if taken during pregnancy, so women of childbearing age should use effective contraception.
Pregnancy and Breastfeeding
Eppilion Chrono 500mg is not recommended during pregnancy due to the risk of birth defects. Women who are pregnant or planning to become pregnant should discuss alternative treatments with their healthcare provider. Breastfeeding is not recommended while taking this medication.
Interactions
- May interact with other anticonvulsants, potentially altering their effectiveness
- Can increase the effects of medications that cause drowsiness
- May interact with certain antibiotics and antidepressants
- Can affect the efficacy of oral contraceptives
Important Information
Take Eppilion Chrono 500mg exactly as prescribed, usually once daily with or without food. Do not crush, chew, or break the tablets as this can affect the extended-release mechanism. Regular follow-ups with your healthcare provider are essential to monitor your response to the medication and adjust the dosage if needed. Do not stop taking this medication abruptly without consulting your doctor, as this can lead to withdrawal seizures.
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| Category | Dosage Instructions |
|---|---|
| Adults (Epilepsy - Initial Dose) | Starting dose: 600 mg per day, divided into 1-2 doses. Gradually increase by 200 mg every 3 days until seizures are controlled. |
| Adults (Epilepsy - Maintenance Dose) | Maintenance dose: 1000-2000 mg per day, divided into 1-2 doses. Maximum dose: 2500 mg/day. |
| Adults (Bipolar Disorder) | Starting dose: 600 mg per day, increasing gradually by 200 mg every 3 days. Maintenance dose: 1000-2000 mg/day in divided doses. |
| Elderly | Start with a lower dose, with close monitoring of clinical response and side effects. Dosage should be carefully titrated. |
| Children (Above 20 kg) | Starting dose: 400 mg per day, gradually increasing by 20-30 mg/kg/day. Maintenance dose: 20-30 mg/kg/day. Maximum dose: 35 mg/kg/day. |
| Children (Below 20 kg) | Dose based on body weight, typically 20 mg/kg/day, gradually increasing by 5-10 mg/kg/day. Maximum dose: 40 mg/kg/day. |
| Renal/Hepatic Impairment | Dose adjustments required based on liver or kidney function. Regular monitoring of liver enzymes is recommended. Consult a healthcare provider for precise dosing. |
Important Notes:
- Eppilion Chrono is a controlled-release formulation and should be swallowed whole, not crushed or chewed.
- Take with food to reduce stomach upset.
- Regular blood tests may be required to monitor liver function and blood cell counts, especially in the first six months of therapy.
- Avoid alcohol while taking this medication, as it can increase the risk of side effects such as drowsiness and liver issues.
- Do not stop taking the medication suddenly without consulting a healthcare provider, as it may trigger seizures or cause withdrawal symptoms.
- Notify your doctor if you experience unusual bruising, bleeding, or yellowing of the skin (signs of liver problems).
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