Natrilix SR Tablet 1.5mg (Indapamide) x30

Natrilix SR 1.5mg is a once-daily extended-release tablet containing indapamide, a diuretic medication used for the treatment of hypertension (high blood pressure). This formulation ensures a sustained release of the active ingredient throughout the day, providing effective and consistent blood pressure control.

Uses

Natrilix SR treats essential hypertension as first-line therapy or in combination with other antihypertensives. It’s used for edema associated with heart failure, liver cirrhosis, or kidney disease. Natrilix SR helps reduce cardiovascular risks including stroke and heart attack in hypertensive patients.

Benefits

• Provides 24-hour blood pressure control with once-daily dosing
• Reduces risk of stroke and cardiovascular events
• Effective as monotherapy or combination treatment
• Maintains electrolyte balance better than other diuretics
• Reduces left ventricular hypertrophy in hypertensive patients
• Improves arterial compliance and endothelial function
• Lower risk of metabolic side effects compared to thiazides
• Well-tolerated with minimal impact on glucose levels
• Suitable for elderly patients with hypertension

How It Works

Natrilix SR works by inhibiting sodium and chloride reabsorption in the distal convoluted tubule of the kidney, promoting diuresis and reducing blood volume. Additionally, it has direct vasodilatory effects on blood vessels, further reducing blood pressure independent of its diuretic action.

Dosage

Take Natrilix SR in the morning with or without food. Swallow whole without crushing or chewing the sustained-release tablet.

Duration of Action

Natrilix SR begins working within 1-2 hours of administration, with peak effects occurring 12 hours post-dose. The sustained-release formulation provides consistent blood pressure control for 24 hours, allowing convenient once-daily dosing. Maximum antihypertensive effects are typically achieved within 8-12 weeks.

Side Effects

Most patients tolerate Natrilix SR well. Common side effects include mild dizziness, headache, and fatigue. Some may experience dry mouth, nausea, or muscle cramps. Rare but serious effects include severe electrolyte imbalances, kidney dysfunction, or allergic skin reactions requiring medical attention.

Warning

Monitor kidney function and electrolyte levels regularly, especially potassium and sodium. Natrilix SR may worsen kidney disease or cause severe dehydration. Use with caution in patients with liver disease, diabetes, or gout. Discontinue if severe skin reactions, kidney problems, or electrolyte abnormalities develop.

Pregnancy and Breastfeeding

Natrilix SR is not recommended during pregnancy as it may cause fetal harm and reduce placental blood flow. Use only if benefits clearly outweigh risks. Limited data exists on breastfeeding safety, so alternative antihypertensive treatments are preferred for nursing mothers.

Interaction

• May enhance effects of other antihypertensive medications
• Increased risk of kidney toxicity with NSAIDs or ACE inhibitors
• May reduce effectiveness of antidiabetic medications
• Potential for dangerous electrolyte changes with corticosteroids
• Lithium levels may increase, requiring dose adjustments

Precaution

Monitor blood pressure, kidney function, and electrolytes regularly during treatment. Use cautiously in elderly patients prone to dehydration. Avoid excessive sun exposure as photosensitivity may occur. Inform healthcare providers about Natrilix SR use before surgery or medical procedures requiring anesthesia.

Important Information

Natrilix SR requires regular monitoring of blood pressure and kidney function. Maintain adequate fluid intake unless specifically restricted. Rise slowly from sitting or lying positions to prevent dizziness. Store at room temperature in original packaging. Do not stop taking suddenly without consulting your doctor, as blood pressure may rebound.