Oxispa Suspension Dry Syrup is an oral antibiotic medication designed to treat a wide range of bacterial infections in both adults and children. This dry syrup formulation contains cefuroxime, a second-generation cephalosporin antibiotic, which is highly effective against various gram-positive and gram-negative bacteria.
Uses
Oxispa Suspension Dry Syrup is indicated for the treatment of various bacterial infections, including:
- Respiratory tract infections (e.g., bronchitis, pneumonia, tonsillitis)
- Urinary tract infections (e.g., cystitis, pyelonephritis)
- Skin and soft tissue infections (e.g., cellulitis, impetigo)
- Ear, nose, and throat infections (e.g., otitis media, sinusitis)
- Bone and joint infections (e.g., osteomyelitis)
- Meningitis (caused by susceptible bacteria)
This broad-spectrum antibiotic can be used to combat infections caused by bacteria such as Streptococcus, Staphylococcus, Haemophilus influenzae, Moraxella catarrhalis, and certain strains of Escherichia coli and Klebsiella.
NOTE: The usual drug of choice in the treatment and prevention of streptococcal infections, including the prophylaxis of rheumatic fever, is penicillin given by the intramuscular route.
Benefits
Oxispa Suspension Dry Syrup offers several benefits in the treatment of bacterial infections:
- Broad-spectrum activity: Cefuroxime is effective against a wide range of gram-positive and gram-negative bacteria, making it a versatile treatment option.
- Convenient oral administration: The dry syrup formulation allows for easy preparation and oral administration, making it suitable for both adults and children.
- Proven efficacy: Cefuroxime has been extensively studied and has demonstrated reliable clinical effectiveness in treating various bacterial infections.
- Suitable for outpatient and inpatient settings: Oxispa Suspension Dry Syrup can be prescribed for both outpatient and inpatient treatment, depending on the severity and site of the infection.
Mechanism of Action
Cefuroxime, the active ingredient in Oxispa Suspension Dry Syrup, belongs to the cephalosporin class of antibiotics. It works by inhibiting the synthesis of the bacterial cell wall, which is essential for the survival and growth of bacteria. Cefuroxime binds to and inactivates specific enzymes called penicillin-binding proteins (PBPs), which are involved in the formation of the cell wall. This disruption in the cell wall synthesis ultimately leads to the destruction of the bacterial cell and the eradication of the infection.
Dosage
| Indication | Dosage |
|---|---|
| Acute tonsillitis and pharyngitis, acute bacterial sinusitis | |
| Children aged two years or older with otitis media or, where appropriate, with more severe infections | 15 mg/kg twice daily to a maximum of 250 mg twice daily |
| Cystitis | 15 mg/kg twice daily to a maximum of 250 mg twice daily |
| Pyelonephritis | 15 mg/kg twice daily to a maximum of 250 mg twice daily for 10 to 14 days |
| Uncomplicated skin and soft tissue infections | 15 mg/kg twice daily to a maximum of 250 mg twice daily |
| Lyme disease | 15 mg/kg twice daily to a maximum of 250 mg twice daily for 14 days (10 to 21 days) |
| Note:Â There is no experience of using Cefuroxime axetil in children under the age of 3 months. |
The dosage of Oxispa Suspension Dry Syrup depends on the patient’s age, weight, and the type and severity of the infection. It is typically administered orally, with or without food, every 12 or 24 hours, as directed by a healthcare professional. It is crucial to follow the prescribed dosage and duration of treatment to ensure complete eradication of the bacterial infection and prevent the development of antibiotic resistance.
Side Effects
Like most antibiotics, Oxispa Suspension Dry Syrup may cause side effects, some of which can be mild and temporary. Common side effects may include:
- Gastrointestinal disturbances (e.g., diarrhea, nausea, vomiting)
- Rash or skin reactions
- Headache
- Dizziness
- Vaginal yeast infection
Serious but rare side effects may include:
- Allergic reactions (e.g., anaphylaxis)
- Clostridium difficile-associated diarrhea
- Blood disorders (e.g., neutropenia, thrombocytopenia)
- Kidney or liver dysfunction
Warning
Oxispa Suspension Dry Syrup should be used with caution in individuals with known allergies to cephalosporin antibiotics or any of the ingredients in the formulation. It should also be used cautiously in patients with impaired renal function, as dose adjustments may be necessary.
Important Information
Oxispa Suspension Dry Syrup is a prescription medication and should only be used under the guidance of a qualified healthcare professional. Patients should provide their complete medical history, including any allergies, current medications, and underlying conditions, to ensure safe and effective use of the antibiotic.
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