Teva Atorvastatin 40mg is a high-potency statin medication designed to effectively manage cholesterol levels. This generic equivalent of Lipitor® contains atorvastatin calcium as its active ingredient, offering a cost-effective solution for patients requiring significant lipid control.
Uses
Teva Atorvastatin 40mg is primarily used for:
- Prevention of cardiovascular events in high-risk patients
- Secondary prevention in patients with established coronary heart disease
- Treatment of hypercholesterolemia and mixed dyslipidemia
- Management of homozygous familial hypercholesterolemia
- Slowing the progression of atherosclerosis
Benefits
- Significantly reduces LDL (bad) cholesterol levels
- Moderately increases HDL (good) cholesterol
- Lowers triglyceride levels
- Decreases the risk of heart attack and stroke
- Slows the progression of atherosclerosis
- Offers a cost-effective alternative to brand-name statins
How It Works
Atorvastatin functions by inhibiting HMG-CoA reductase, a key enzyme in cholesterol biosynthesis. This action leads to increased expression of LDL receptors on liver cells, enhancing the clearance of LDL cholesterol from the bloodstream. Additionally, it modestly increases HDL cholesterol and reduces triglycerides.
Dosage
The typical starting dose is 10-20mg once daily, with 40mg being a higher strength for patients requiring more intensive lipid-lowering therapy. The maximum recommended dose is 80mg daily. Dosage should be individualized based on baseline LDL-C levels, the goal of therapy, and patient response.
Side Effects
Common side effects may include mild muscle pain, constipation, and elevated liver enzymes. Rare but serious side effects can include myopathy, rhabdomyolysis, and liver dysfunction. Regular monitoring of liver function and muscle symptoms is recommended.
Warning
Teva Atorvastatin 40mg should be used with caution in patients with a history of liver disease, heavy alcohol use, or those at risk for myopathy. It is contraindicated during pregnancy and lactation. Patients should report any unexplained muscle pain, tenderness, or weakness promptly to their healthcare provider.
Interaction
- Increased risk of myopathy with fibrates, especially gemfibrozil
- Enhanced effect when combined with ezetimibe
- Potential interaction with strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole)
- Increased risk of rhabdomyolysis when used with colchicine
- May increase the plasma concentration of digoxin
Important Information
Teva Atorvastatin 40mg should be taken as part of a comprehensive approach to cholesterol management, including diet and exercise. Regular lipid profile monitoring is essential to assess efficacy and adjust treatment as needed. Grapefruit products should be avoided due to potential interactions.
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