Vastarel MR 35mg is a modified-release tablet containing trimetazidine, an innovative anti-ischemic agent. This medication optimizes cardiac energy metabolism and provides protective effects against angina pectoris. It’s specifically designed for long-term management of coronary artery disease and vertigo symptoms.
Uses
Vastarel MR is primarily prescribed for treating stable angina pectoris in adults. It’s used as a second-line therapy in patients who continue experiencing symptoms despite first-line anti-anginal treatments. The medication also helps manage symptoms of vertigo, tinnitus, and visual disturbances.
Benefits
- Reduces frequency and severity of angina attacks
- Improves exercise tolerance in chronic angina
- Decreases need for nitrate consumption
- Enhances cardiac energy metabolism
- Provides protective effects against ischemia
- Helps manage vestibular vertigo symptoms
- Minimizes visual disturbances
- Offers convenient twice-daily dosing
How It Works
Vastarel MR works by optimizing cellular energy metabolism. It selectively inhibits long-chain 3-ketoacyl-CoA thiolase, promoting glucose utilization over fatty acid oxidation. This metabolic shift helps protect cardiac cells during oxygen-deficient conditions, improving heart function and reducing angina symptoms.
Duration of Action
The modified-release formulation provides sustained drug levels over 12 hours. Initial benefits may be noticed within 2 weeks, with optimal therapeutic effects typically achieved after 4-6 weeks of regular use. The full anti-anginal effect is maintained throughout the treatment period.
Dosage
Standard dosing is one 35mg tablet twice daily with meals, taken in the morning and evening. Elderly patients and those with moderate kidney impairment may require dose adjustment. Maintain consistent timing of doses for optimal results.
Side Effects
Most side effects are mild and transient. Common effects include gastrointestinal disturbances, headache, and dizziness. Rare side effects may include palpitations, skin rashes, and muscle weakness. Most patients tolerate the medication well with long-term use.
Warning
Discontinue use and seek immediate medical attention if experiencing symptoms of allergic reactions, severe dizziness, or unusual heart rhythm changes. Regular monitoring of kidney function may be required during long-term treatment.
Pregnancy and Breastfeeding
Not recommended during pregnancy unless clearly necessary. Avoid use while breastfeeding due to limited safety data. Women of childbearing age should discuss family planning with their healthcare provider before starting treatment.
Interactions
- May interact with certain antiarrhythmic medications
- Caution with medications affecting heart rhythm
- Possible interactions with strong CYP450 inhibitors
- Monitor when used with other anti-anginal drugs
- May affect response to vasodilator medications
Important Information
Store below 30°C in a dry place. Don’t stop treatment abruptly without medical advice. Regular medical check-ups are essential to monitor treatment effectiveness. Report any new or worsening symptoms to your healthcare provider. Missing a dose: Take as soon as remembered unless it’s almost time for the next dose.
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