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Zoldric Injection (Zoledronic Acid) 4ml

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Zoldric Injection is used to reduce the risk of fractures and improve bone density, paget’s disease of bone, a chronic disorder that causes abnormal bone.


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Zoldric Injection is a powerful intravenous medication containing zoledronic acid, a potent bisphosphonate compound used to treat various bone disorders and complications. This injectable formulation offers targeted and effective treatment for conditions involving abnormal bone resorption or excessive bone loss.


Zoldric Injection is primarily used in the treatment of:

  • Osteoporosis in postmenopausal women, to reduce the risk of fractures and improve bone density
  • Bone complications of cancer
  • Paget’s disease of bone, a chronic disorder that causes abnormal bone remodeling
  • Bone metastases and hypercalcemia associated with certain types of cancer
  • Multiple myeloma, a cancer of the plasma cells in bone marrow


  • Helps prevent and treat osteoporosis by inhibiting excessive bone resorption and increasing bone mineral density
  • Provides relief from bone pain and reduces the risk of fractures in patients with bone metastases
  • Effectively manages hypercalcemia (elevated calcium levels) associated with malignancies
  • Slows the progression of Paget’s disease and reduces bone deformities and complications

Mechanism of Action

Zoledronic acid, the active ingredient in Zoldric Injection, belongs to the class of bisphosphonate drugs. It works by inhibiting osteoclast activity, which is responsible for bone resorption (breakdown). By suppressing excessive osteoclast function, zoledronic acid helps maintain the balance between bone formation and resorption, leading to increased bone mass and reduced risk of fractures.


Zoldric Injection is administered intravenously (IV) by a healthcare professional in a controlled medical setting. The dosage and frequency of administration may vary depending on the specific condition being treated and the patient’s individual needs. It is crucial to follow the dosing instructions provided by your healthcare provider.

Side Effects

Like many potent medications, Zoldric Injection may cause side effects in some patients. Common side effects may include flu-like symptoms, fever, muscle pain, nausea, and bone or joint pain. More serious side effects, such as kidney problems, low calcium levels, and osteonecrosis of the jaw, may occur in rare cases. Report any severe or persistent side effects to your healthcare provider immediately.


Zoldric Injection should be used with caution in patients with kidney impairment, as dosage adjustments may be necessary. It should also be avoided in patients with hypocalcemia (low calcium levels) or those with known allergies or hypersensitivity to zoledronic acid or other bisphosphonates.

Important Information

  • Zoldric Injection is administered under the supervision of a healthcare professional and should not be self-administered.
  • Adequate calcium and vitamin D intake is essential during treatment to prevent hypocalcemia.
  • Patients should maintain good oral hygiene and undergo routine dental check-ups, as osteonecrosis of the jaw is a potential risk with long-term bisphosphonate use.
  • Regular monitoring of kidney function and calcium levels may be necessary during treatment.

Zoldric Injection offers an effective and targeted approach to managing various bone disorders and complications. However, it should be used under the guidance of a healthcare professional, and patients should be aware of the potential risks and benefits associated with this potent medication.

How to Use Zoldric Injection (Zoledronic Acid)


  1. Prescription:
    • Ensure you have a prescription from a healthcare provider.
  2. Healthcare Setting:
    • Zoledronic acid is typically administered by a healthcare professional in a clinical setting due to the need for intravenous (IV) administration and potential monitoring during and after the infusion.
  3. Dilution:
    • Zoldric Injection usually comes in a concentrate that must be diluted before use. Follow the specific product instructions for dilution. Generally, it is diluted in 100 ml of sterile saline or 5% dextrose solution.


  1. Dosage:
    • The typical dosage is 4 mg, given as a single intravenous infusion over no less than 15 minutes. The frequency of administration can vary depending on the condition being treated:
      • Osteoporosis: Usually given once a year.
      • Paget's Disease: Typically a single dose.
      • Bone Metastases and Cancer-related Conditions: Every 3 to 4 weeks, as prescribed.
  2. Infusion:
    • The prepared solution is infused intravenously over a minimum of 15 minutes.
  3. Hydration:
    • Ensure the patient is well-hydrated before the infusion. Patients may be advised to drink fluids before and after the infusion to prevent kidney complications.

Monitoring and Aftercare

  1. Monitor for Side Effects:
    • Common side effects include flu-like symptoms, fever, muscle or joint pain, and headache. Severe side effects may include kidney dysfunction, hypocalcemia, and osteonecrosis of the jaw. Patients should be monitored during and after the infusion.
  2. Lab Tests:
    • Regular blood tests to monitor kidney function, calcium levels, and other electrolytes may be required before and after treatment.
  3. Calcium and Vitamin D:
    • Patients should ensure adequate intake of calcium and vitamin D, as zoledronic acid can cause hypocalcemia.

Important Considerations

  1. Pre-existing Conditions:
    • Inform your healthcare provider of any pre-existing conditions, especially kidney issues, dehydration, low blood calcium levels, or dental problems.
  2. Pregnancy and Breastfeeding:
    • Zoledronic acid is not typically recommended during pregnancy or breastfeeding. Discuss potential risks with your healthcare provider.
  3. Drug Interactions:
    • Inform your healthcare provider about all other medications you are taking, as some drugs can interact with zoledronic acid.


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