Glucovance 500/5mg Tablet containing 500mg metformin combined with 5mg glibenclamide for management of type 2 diabetes mellitus in patients with insufficient glycemic control.
Uses
Glucovance 500/5mg is Primarily prescribed as add-on therapy with diet and exercise for adult T2DM patients struggling with hyperglycemia control using metformin alone based on complementary mechanisms.
Benefits
The dual antihyperglycemic agents provide enhanced reduction in blood glucose levels compared to metformin alone. Maintains glycated hemoglobin closer to normal ranges.
Mechanism of Action
Metformin reduces hepatic glucose production and improves insulin sensitivity. Glibenclamide stimulates insulin secretion from pancreatic beta cells. Together the effects optimize blood sugar control.
Dosage
The usual adult dose is 1 tablet twice daily with meals, though this may be adjusted based on clinical indicators. Follow physician instructions.
Warnings
- May cause low blood sugar – monitor levels
- Use with caution in liver/kidney dysfunction
- Not for type 1 diabetes management
Important Information
- Drink plenty of fluids when taking
- Never share tablets with others
- Report any muscle pain or respiratory issues
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