Oxyurea 500mg is a specialized antimetabolite medication containing hydroxyurea, designed to slow abnormal cell growth. This prescription-only medication requires careful medical supervision and is crucial in treating various blood disorders and certain types of cancer.
Uses
Oxyurea treats chronic myeloid leukemia, polycythemia vera, and sickle cell anemia. It’s particularly effective in reducing pain crises in sickle cell disease and managing excessive red blood cell production in polycythemia vera.
Benefits
- Reduces frequency of pain crises
- Decreases need for blood transfusions
- Lowers hospitalization rates
- Controls abnormal cell growth
- Manages blood disorders effectively
- Oral administration convenience
- Extends disease remission periods
- Alternative to surgical intervention
How It Works
Oxyurea works by inhibiting DNA synthesis in rapidly dividing cells, specifically targeting the enzyme ribonucleotide reductase. This action helps control abnormal cell growth and modify blood cell production.
Dosage
| Condition | Dosage | Duration and Frequency |
|---|---|---|
| Initial Dose | 500mg | Once daily, adjust based on response |
| Maintenance | As prescribed | Based on blood count monitoring |
| Maximum Dose | 2000mg | Daily dose not to exceed |
Duration of Action
Effects on blood counts typically observed within 24 hours. Maximum therapeutic benefit achieved within 2-3 months of consistent use. Regular monitoring required to maintain optimal dosing.
Side Effects
Common side effects include nausea, fatigue, and decreased blood counts. Serious side effects may include skin ulcers, severe infections, or nerve problems. Regular blood monitoring essential.
Warning
Seek immediate medical attention if experiencing fever, unusual bleeding, severe skin reactions, or breathing difficulties. Regular blood tests required to monitor treatment response and adjust dosage.
Pregnancy and Breastfeeding
Contraindicated during pregnancy due to risk of fetal harm. Must avoid breastfeeding during treatment. Effective contraception required during therapy.
Interactions
- Live vaccines
- Other chemotherapy drugs
- Antiretroviral medications
- Bone marrow suppressants
- NSAIDs
Precautions
Regular blood count monitoring required. Maintain adequate hydration. Report any signs of infection promptly. Use effective contraception. Follow strict hygiene practices to prevent infection.
Important Information
Take exactly as prescribed. Never adjust dose without medical consultation. Keep all monitoring appointments. Report any new symptoms immediately. Store in a secure location away from light and moisture.
Maintain detailed records of side effects and symptoms. Emergency contact information should be readily available.
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