Primolut N contains Norethisterone, a synthetic progestin hormone used for gynecological purposes. This medication regulates menstrual cycles, provides contraception, treats menstrual disorders, and manages endometriosis by altering natural hormone levels.
Uses
Primolut N is prescribed for contraception, treating irregular or heavy menstrual periods, managing endometriosis symptoms, hormone replacement therapy, and as adjunct treatment in specific breast cancer cases. It effectively addresses various gynecological conditions requiring hormonal intervention.
Benefits
- Provides effective contraception when used correctly
- Regulates irregular menstrual cycles
- Reduces heavy menstrual bleeding significantly
- Alleviates endometriosis-related pain and symptoms
- Supports hormone replacement therapy protocols
- May benefit certain breast cancer treatment regimens
- Helps manage premenstrual syndrome symptoms
- Offers flexible dosing options for different conditions
- Generally well-tolerated by most women
How It Works
Norethisterone mimics natural progesterone effects in the body. It alters the uterine lining and cervical mucus, making it difficult for sperm to reach an egg and preventing fertilized egg implantation. The hormone also regulates menstrual cycles and reduces excessive bleeding by controlling endometrial growth.
Dosage
Condition | Typical Dosage | Duration |
---|---|---|
Contraception | 0.35mg daily | Continuous |
Menstrual Disorders | 2.5-5mg daily | 5-10 days per cycle |
Endometriosis | 2.5mg 2-3× daily | 4-6 months |
Take Primolut N at the same time daily with water, preferably after meals to reduce nausea.
Duration of Action
Primolut N begins working within hours of administration. For contraceptive purposes, effectiveness starts immediately if begun on day 1 of menstrual cycle. Menstrual regulation typically occurs within one cycle, while endometriosis symptoms may improve after 2-3 months of consistent use.
Side Effects
Common side effects include nausea, bloating, breast tenderness, weight changes, headaches, and mood fluctuations. Some women experience breakthrough bleeding, acne, or decreased libido. Most side effects are mild and often resolve as the body adjusts to treatment.
Warning
Primolut N increases blood clot risk, especially in smokers over 35. It’s contraindicated in pregnancy, undiagnosed vaginal bleeding, liver disease, or history of blood clots. This medication doesn’t protect against sexually transmitted infections and may mask pregnancy symptoms.
Pregnancy and Breastfeeding
Primolut N is contraindicated during pregnancy as it may cause fetal abnormalities. Discontinue immediately if pregnancy is suspected. Small amounts pass into breast milk but are generally considered safe during breastfeeding, though it may reduce milk production in some women.
Interaction
- May reduce effectiveness of anticoagulant medications
- Certain antibiotics may decrease contraceptive effectiveness
- Anticonvulsants can reduce Primolut N efficacy
- May alter blood sugar levels in diabetic patients
- Possible interaction with St. John’s Wort reducing effectiveness
- May enhance effects of corticosteroids
Precaution
Use cautiously in patients with diabetes, hypertension, depression, or migraine history. Regular monitoring is required for liver function and blood pressure. Women with family history of breast cancer need careful evaluation. Avoid smoking while taking Primolut N to minimize clot risk.
Important Information
Primolut N requires regular medical check-ups including blood pressure monitoring and cervical screenings. Report unusual vaginal bleeding, severe headaches, or leg pain immediately. For contraceptive use, additional barrier methods are recommended for STI protection. Store at room temperature away from moisture and heat.
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