Maldox Suspension is a prescription medication containing two active ingredients: sulfadoxine and pyrimethamine. This antifolate drug is primarily used for the treatment and prevention of specific types of malaria.
Uses
Maldox Suspension is indicated for:
- Treatment of uncomplicated Plasmodium falciparum malaria
- Intermittent preventive treatment (IPT) of malaria during pregnancy in high-risk areas
Benefits
- Effective in treating uncomplicated Plasmodium falciparum malaria
- Helps prevent malaria in pregnant women, reducing the risk of complications
- Convenient oral suspension formulation for ease of administration
- May be used as part of combination therapy for improved efficacy
How It Works
Sulfadoxine and pyrimethamine work synergistically to disrupt the folate metabolism of the malaria parasite, inhibiting its growth and replication. By blocking the synthesis of essential folate derivatives, these agents prevent the parasite from multiplying within the host’s red blood cells.
Dosage
The dosage of Maldox Suspension depends on the patient’s weight:
| Age/Weight | Dosage |
|---|---|
| 0-1 year (5-10 kg) | 2.5 ml single dose |
| 1-3 years (11-20 kg) | 5 ml single dose |
| 4-6 years (21-30 kg) | 7.5 ml single dose |
| 7-10 years (31-45 kg) | 10 ml single dose |
| >10 years (>45 kg) | 15 ml single dose |
Always follow the healthcare professional’s instructions and complete the entire course of treatment as prescribed.
Side Effects
Common side effects may include nausea, vomiting, diarrhea, abdominal pain, and skin rash. Rare but more severe side effects can occur. Seek medical attention if you experience any severe or persistent side effects.
Warning
Maldox Suspension should be used with caution in individuals with severe renal or hepatic impairment, folate deficiency, or a history of hypersensitivity to sulfonamides or pyrimethamine. Inform your healthcare provider about any other medications you are taking to avoid potential drug interactions.
Pregnancy and Breastfeeding
Maldox Suspension is used for malaria prevention during pregnancy in high-risk areas. However, always consult with your healthcare provider before use, as individual assessment is necessary.
Interaction
- May interact with certain antifolate drugs, potentially increasing side effects
- Can affect the efficacy of some anticonvulsants
- Potential interaction with drugs that affect bone marrow function
- May interfere with certain laboratory tests
Important Information
While Maldox Suspension is effective in treating and preventing malaria, it’s crucial to follow appropriate preventive measures, such as using insect repellents and sleeping under insecticide-treated bed nets. Seek prompt medical attention if malaria symptoms develop. Shake the suspension well before each use and use the measuring device provided for accurate dosing. Store the medication in a cool, dry place away from direct sunlight and out of reach of children.
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