Daonil 5mg Tablet (Glibenclamide) x100

Daonil 5mg Tablet contains Glibenclamide, an oral antidiabetic medication belonging to the sulfonylurea class. This medication helps control blood sugar levels in adults with type 2 diabetes mellitus by stimulating insulin release from the pancreas.

Uses

Daonil 5mg Tablet treats type 2 diabetes mellitus when diet and exercise alone are insufficient to control blood glucose levels. It’s used alongside lifestyle modifications to improve glycemic control and reduce diabetic complications in adults with functioning pancreatic beta cells.

Benefits

• Effectively lowers blood glucose levels
• Reduces risk of diabetic complications
• Helps maintain HbA1c within target range
• Improves insulin sensitivity over time
• Supports pancreatic beta cell function
• Reduces symptoms of hyperglycemia
• Can be combined with other diabetes medications
• Proven track record in diabetes management
• Cost-effective diabetes treatment option

How It Works

Daonil works by binding to sulfonylurea receptors on pancreatic beta cells, stimulating insulin release. This increased insulin secretion helps lower blood glucose levels by promoting glucose uptake into cells and reducing hepatic glucose production. The medication is most effective when some pancreatic function remains.

Dosage

Take Daonil with breakfast or the first main meal. If higher doses are needed, divide into 2-3 doses throughout the day.

Duration of Action

Daonil begins working within 1-2 hours of administration, with peak effects occurring 2-4 hours after taking the dose. The glucose-lowering effect lasts approximately 12-24 hours, allowing once or twice daily dosing for most patients.

Side Effects

Common side effects include hypoglycemia (low blood sugar), weight gain, and mild gastrointestinal upset. Some patients may experience dizziness, headache, or skin reactions. Hypoglycemia symptoms include sweating, shakiness, hunger, and confusion, requiring immediate treatment with glucose.

Warning

Risk of severe hypoglycemia, especially in elderly patients, those with kidney impairment, or irregular meal patterns. Daonil may lose effectiveness over time as pancreatic function declines. Not suitable for type 1 diabetes or diabetic ketoacidosis. Alcohol consumption increases hypoglycemia risk.

Pregnancy and Breastfeeding

Daonil is contraindicated during pregnancy as it crosses the placenta and may cause fetal hypoglycemia. Insulin is preferred for diabetes management during pregnancy. Glibenclamide passes into breast milk, so breastfeeding mothers should consult their healthcare provider about safer alternatives.

Interaction

• Increased hypoglycemia risk with alcohol, beta-blockers, or certain antibiotics
• Reduced effectiveness with corticosteroids, thiazide diuretics, or phenytoin
• Enhanced effects when combined with ACE inhibitors or fibrates
• May interact with warfarin, affecting blood clotting
• Certain medications may mask hypoglycemia symptoms

Precaution

Use cautiously in patients with kidney or liver impairment, elderly individuals, or those with irregular eating patterns. Monitor blood glucose regularly, especially during illness, stress, or changes in medication. Patients should carry glucose tablets for hypoglycemia treatment. Regular HbA1c monitoring is essential.

Important Information

Daonil is part of comprehensive diabetes management including diet, exercise, and regular monitoring. Never skip meals while taking this medication due to hypoglycemia risk. Inform all healthcare providers about Daonil use before procedures or starting new medications. Store at room temperature away from moisture and heat. Regular follow-up appointments are crucial for optimal diabetes control.