Ethiclox Capsule 500mg (Ampicillin+Cloxacillin) x100

Ethiclox Capsule 500mg combines Ampicillin and Cloxacillin (250mg each), providing broad-spectrum antibiotic coverage. This dual-action formulation effectively treats both gram-positive and gram-negative bacterial infections, including penicillinase-producing strains.

Uses

Ethiclox Capsule treats respiratory tract infections, skin and soft tissue infections, urinary tract infections, otitis media, sinusitis, and dental infections. It’s particularly effective against mixed infections and when the specific pathogen is unknown, offering coverage against both penicillin-sensitive and resistant organisms.

Benefits

• Provides broad-spectrum antibacterial coverage
• Effective against penicillinase-producing bacteria
• Treats both gram-positive and gram-negative infections
• Reduces risk of treatment failure in mixed infections
• Offers synergistic action against certain pathogens
• Prevents bacterial cell wall synthesis
• Shows rapid clinical response in many infections
• Suitable for empiric therapy before culture results
• Well-established safety profile

How It Works

Ampicillin targets gram-negative bacteria by inhibiting cell wall synthesis. Cloxacillin resists destruction by penicillinase enzymes, effectively treating penicillinase-producing staphylococci. Together, they bind to bacterial penicillin-binding proteins, disrupting cell wall formation and causing bacterial cell death.

Dosage

Take Ethiclox consistently at evenly spaced intervals with a full glass of water, preferably 1 hour before or 2 hours after meals for optimal absorption.

Duration of Action

Ethiclox begins working within 1 hour of administration. Peak blood levels occur at 1-2 hours. The antibacterial action continues for 4-6 hours per dose. Complete treatment courses typically last 5-10 days, depending on the type and severity of infection.

Side Effects

Common side effects include mild gastrointestinal disturbances like nausea, vomiting, or diarrhea. Some patients experience mild skin rash or itching. Less common effects include antibiotic-associated diarrhea or oral candidiasis. Serious allergic reactions are rare but require immediate medical attention.

Warning

Complete the full prescribed course even if symptoms improve. Premature discontinuation may lead to bacterial resistance or recurrence. Ethiclox can cause serious allergic reactions, including anaphylaxis, especially in patients allergic to penicillins or cephalosporins. Seek immediate medical attention for difficulty breathing, severe rash, or swelling.

Pregnancy and Breastfeeding

Ethiclox is generally considered safe during pregnancy when clearly needed. Animal studies show no harm to fetuses, but human data is limited. Both antibiotics pass into breast milk in small amounts. Consult healthcare provider before using while breastfeeding, as it may cause diarrhea or allergic sensitization in nursing infants.

Interaction

• May reduce effectiveness of oral contraceptives
• Possible increased risk of rash with allopurinol
• May affect results of certain laboratory tests
• Probenecid increases blood levels of both antibiotics
• Potential decreased effectiveness with tetracyclines
• Possible interaction with methotrexate

Precaution

Use with caution in patients with history of allergies, asthma, or hay fever. Patients with kidney impairment may require dosage adjustment. Prolonged use may result in superinfection. Monitor for signs of pseudomembranous colitis. Not effective against viral infections such as common cold or flu.

Important Information

Ethiclox is prescription-only and should be used only for bacterial infections. Take at evenly spaced intervals to maintain constant blood levels. Complete the full prescribed course. Contact healthcare provider if symptoms persist after several days or worsen during treatment. Store at room temperature away from heat and moisture.