Human Insulatard Injection 40IU x10ml vial

Human Insulatard Injection 40IU is an intermediate-acting isophane insulin injection containing monocomponent human insulin produced by recombinant DNA technology. This subcutaneous suspension provides extended blood glucose control for diabetes management.

Uses

Human Insulatard treats Type 1 and Type 2 diabetes mellitus requiring insulin therapy. It’s used for basal insulin coverage, maintaining steady glucose levels between meals and overnight. Insulatard is suitable for patients needing intermediate-acting insulin as part of comprehensive diabetes management plans.

Benefits

• Provides 12-24 hours of glucose control
• Offers flexible dosing for basal insulin needs
• Reduces risk of diabetic complications
• Maintains steady blood glucose levels
• Compatible with rapid-acting insulin combinations
• Suitable for once or twice daily administration
• Helps prevent dawn phenomenon hyperglycemia
• Cost-effective diabetes management option
• Well-established safety profile over decades of use

How It Works

Human Insulatard contains NPH (Neutral Protamine Hagedorn) insulin that forms crystals when injected subcutaneously. These crystals slowly dissolve, providing gradual insulin release over 12-24 hours. The insulin binds to receptors, facilitating glucose uptake by cells and suppressing hepatic glucose production.

Dosage

Inject subcutaneously in thigh, abdomen, or upper arm. Rotate injection sites to prevent lipodystrophy. Timing depends on individual needs and meal patterns.

Duration of Action

Human Insulatard begins working 1-2 hours after injection, peaks at 6-12 hours, and lasts 18-24 hours. The onset, peak, and duration may vary between individuals based on injection site, dose, and physical activity levels.

Side Effects

Most common side effect is hypoglycemia, especially with missed meals or increased activity. Local injection site reactions include redness, swelling, or itching. Some patients experience lipodystrophy at injection sites. Weight gain may occur due to improved glucose utilization and increased appetite.

Warning

Never inject Human Insulatard intravenously or intramuscularly. Monitor blood glucose regularly to prevent severe hypoglycemia. Dosage adjustments needed during illness, stress, or changes in diet and exercise. Always carry glucose tablets or quick-acting carbohydrates for hypoglycemia treatment.

Pregnancy and Breastfeeding

Human Insulatard is safe during pregnancy and often preferred over oral diabetes medications. Insulin requirements typically increase during pregnancy and may change postpartum. Breastfeeding mothers may need dosage adjustments as breastfeeding can affect blood glucose levels.

Interaction

• Beta-blockers may mask hypoglycemia symptoms
• Corticosteroids may increase insulin requirements
• ACE inhibitors may enhance insulin sensitivity
• Alcohol may cause delayed hypoglycemia
• Some medications may affect blood glucose requiring dose adjustments

Precaution

Store unopened vials in refrigerator, never freeze. Once opened, store at room temperature up to 42 days. Gently roll vial before use to ensure proper mixing. Check expiration dates regularly. Patients with kidney or liver disease may require dosage adjustments and closer monitoring.

Important Information

Human Insulatard requires proper injection technique and site rotation. Regular blood glucose monitoring is essential for optimal diabetes control. Maintain consistent meal timing and carbohydrate intake. Inform healthcare providers about insulin use before medical procedures. Always have emergency glucose supplies available for hypoglycemia treatment.