Loxagyl 400mg Tablet (Metronidazole) x100

Loxagyl 400mg Tablet contains Metronidazole as its active ingredient. It’s an antibiotic and antiprotozoal medication used to treat various bacterial and parasitic infections. Loxagyl is effective against anaerobic bacteria and certain parasites.

Uses

• Bacterial infections of the stomach, skin, joints, and respiratory tract
• Parasitic infections such as amoebiasis and giardiasis
• Dental infections
• Bacterial vaginosis
• Prevention of infections after certain surgeries

Benefits

• Effective against anaerobic bacteria and protozoa
• Treats wide range of infections including dental and gynecological
• Rapid symptom relief in most infections
• Well-absorbed when taken orally
• Penetrates well into tissues and body fluids
• Cost-effective treatment option
• Available in multiple formulations
• Can be used in combination therapies
• Generally well-tolerated when used appropriately

How It Works

Metronidazole is converted to its active form inside anaerobic bacteria and protozoa. It interferes with DNA synthesis by binding to DNA strands, causing cell death. This selective action makes it highly effective against anaerobic organisms while having minimal impact on normal aerobic bacteria.

Dosage

Take Loxagyl with or after meals to reduce stomach irritation. Swallow tablets whole with water.

Duration of Action

Loxagyl begins working within hours of administration, with peak blood levels reached in 1-2 hours. Therapeutic effects are usually noticeable within 24-48 hours. The medication has a half-life of 6-8 hours, requiring multiple daily doses for optimal effectiveness.

Side Effects

Common side effects include nausea, metallic taste, loss of appetite, and mild stomach upset. Some patients may experience headache, dizziness, or dark-colored urine. Serious side effects like peripheral neuropathy or seizures are rare but require immediate medical attention.

Warning

Avoid alcohol consumption during treatment and for 48 hours after completion, as it can cause severe nausea, vomiting, and flushing. Loxagyl may cause dizziness affecting driving ability. Long-term use may lead to peripheral neuropathy. Inform doctor of any neurological symptoms during treatment.

Pregnancy and Breastfeeding

Loxagyl should be avoided during the first trimester of pregnancy unless benefits clearly outweigh risks. It can be used in later pregnancy when necessary. The medication passes into breast milk, so breastfeeding should be discontinued during treatment and for 12-24 hours after the last dose.

Interaction

• Severe reaction when combined with alcohol or alcohol-containing products
• May enhance effects of warfarin and other anticoagulants
• Can increase lithium levels leading to toxicity
• Possible interaction with certain seizure medications
• May reduce effectiveness of hormonal contraceptives
• Potential interaction with cyclosporine

Precaution

Use with caution in patients with liver disease, neurological disorders, or blood disorders. Monitor for signs of peripheral neuropathy during prolonged treatment. Avoid in patients with known hypersensitivity to metronidazole. Regular monitoring may be needed for extended treatment courses.

Important Information

Complete the full course even if symptoms improve early. Loxagyl may cause false-positive results in certain laboratory tests. Store at room temperature away from moisture and heat. Sexual partners should be treated simultaneously for sexually transmitted infections. Avoid alcohol-containing medications, mouthwashes, and foods during treatment.