Marcfix 352mg Tablet (Cefixime) x10

Marcfix is a powerful combination antibiotic medication containing cefixime 200mg and clavulanic acid 125mg. This dual-action formulation provides enhanced efficacy against resistant bacterial strains by combining a third-generation cephalosporin with a beta-lactamase inhibitor.

Uses

Under medical guidance, Marcfix extended-spectrum antibiotic tablets are commonly prescribed to treat and resolve infections affecting the:

• Sinuses
• Throat, tonsils and pharynx
• Lungs and respiratory tract
• Urinary tract, kidney and bladder
• Reproductive organs
• Skin and soft tissues

Benefits

• Broad spectrum bacteria coverage from two complementary antibiotics
• Clavulanic acid counters beta-lactamase resistance for improved efficacy
• Effective single-tablet treatment for bacterial infections without needing multiple antibiotics
• Lower treatment failure rates for resistant infections

How It Works

Marcfix works through a dual mechanism of action. Cefixime inhibits bacterial cell wall synthesis by binding to specific penicillin-binding proteins, while clavulanic acid protects cefixime from degradation by beta-lactamase enzymes produced by resistant bacteria. This synergistic action allows the antibiotic to overcome resistance mechanisms.

Duration of Action

The medication provides sustained antimicrobial activity with effects lasting approximately 12 hours after administration. Cefixime reaches peak plasma concentrations within 2-6 hours and has a half-life of 3-4 hours, while clavulanic acid has a shorter half-life of approximately 1 hour.

Dosage

Warnings

Immediately inform your doctor if any hypersensitivity reactions, severe diarrhea, or other concerning symptoms manifest when on this therapy. Patients with a history of penicillin, cephalosporin, or beta-lactam antibiotic allergies should use caution with this medication.

Side Effects

Common side effects may include gastrointestinal disturbances such as nausea, vomiting, diarrhea, and abdominal pain. Headache, dizziness, and skin rashes may also occur. Severe but rare side effects include Clostridium difficile-associated diarrhea and severe allergic reactions.

Pregnancy and Breastfeeding

Marcfix should be used during pregnancy only when clearly needed and when potential benefits outweigh possible risks. Small amounts of the medication may pass into breast milk, so caution is advised during breastfeeding.

Interactions

• Probenecid (may increase antibiotic blood levels)
• Anticoagulants (may increase bleeding risk)
• Oral contraceptives (possible reduced effectiveness)
• Antacids (may reduce absorption)
• Methotrexate (increased risk of toxicity)
• Aminoglycosides (synergistic effect, increased risk of nephrotoxicity)

Precautions

Take Marcfix tablets exactly as prescribed at evenly spaced intervals to maintain consistent antibiotic levels. Complete the full course of treatment even if symptoms improve before finishing. Take with food to minimize gastric irritation. Store at room temperature away from moisture and heat.

Important Information

Marcfix tablets provide effective treatment for a wide range of bacterial infections through its dual-antibiotic approach. This medication should only be used for bacterial infections as it is not effective against viral infections. Proper diagnosis and susceptibility testing are important before initiating therapy.