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Uperio 50mg Tablet (Sacubitril/Valsartan) x28

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Uperio 50mg Tablet is used to treat adults with chronic heart failure. It’s specifically indicated for patients with reduced ejection fraction

55,000.00

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SKU:UP-G32

Uperio 50mg Tablet is a prescription medication containing a combination of sacubitril and valsartan. This innovative drug is designed to treat chronic heart failure in adults, offering a new approach to managing this serious condition.

Uses

Uperio 50mg Tablet is primarily used to treat adults with chronic heart failure. It’s specifically indicated for patients with reduced ejection fraction, a condition where the heart muscle doesn’t contract effectively and therefore pumps less oxygen-rich blood to the body.

Benefits

  • Reduces the risk of cardiovascular death and hospitalization due to heart failure
  • Improves heart function and pumping ability
  • Decreases symptoms of heart failure such as shortness of breath and fatigue
  • May slow the progression of heart failure
  • Improves quality of life for patients with chronic heart failure
  • Offers a dual-action approach to heart failure treatment

How It Works

Uperio combines two active ingredients: sacubitril and valsartan. Sacubitril inhibits neprilysin, an enzyme that breaks down natriuretic peptides, which help reduce blood pressure and decrease strain on the heart. Valsartan is an angiotensin receptor blocker (ARB) that relaxes blood vessels and reduces blood pressure. Together, these components work to reduce the strain on the heart, improve its pumping ability, and slow the progression of heart failure.

Dosage

The typical starting dose of Uperio is 49/51 mg (sacubitril/valsartan) twice daily. Your doctor may adjust this dose based on your response to the medication and how well you tolerate it. The maximum recommended dose is 97/103 mg twice daily. Always take Uperio exactly as prescribed by your healthcare provider.

Side Effects

Common side effects of Uperio may include low blood pressure, high blood potassium levels, kidney problems, and cough. Some patients may experience dizziness, lightheadedness, or fainting, especially when starting the medication or when the dose is increased. If you experience severe side effects or allergic reactions, seek medical attention immediately.

Warning

Uperio can cause harm or death to an unborn baby if used during pregnancy. Women who can become pregnant should use effective birth control while taking this medication. Uperio should not be used with ACE inhibitors due to the risk of angioedema. Patients with a history of angioedema or severe kidney problems may not be suitable candidates for this medication.

Pregnancy and Breastfeeding

Uperio 50mg is contraindicated during pregnancy due to the risk of fetal harm. It’s unknown if Uperio passes into breast milk. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternative treatments with their healthcare provider.

Interactions

  • Should not be used with ACE inhibitors
  • May interact with other medications that affect blood pressure
  • Potential interaction with medications that increase potassium levels
  • May interact with certain pain medications (NSAIDs)
  • Could affect the efficacy of some diabetes medications
  • Always inform your healthcare provider about all medications and supplements you’re taking

Important Information

Uperio is a prescription medication and should only be taken under the supervision of a healthcare provider. Regular monitoring of blood pressure, kidney function, and potassium levels is necessary while taking this medication. Do not stop taking Uperio without consulting your doctor, as sudden discontinuation can lead to worsening of heart failure symptoms. Take Uperio with or without food, but be consistent in how you take it. If you miss a dose, take it as soon as you remember unless it’s close to the time for your next dose. In that case, skip the missed dose and continue with your regular schedule.

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Uperio 50mg
Uperio 50mg

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Category Dosage Instructions
Starting Dose 50 mg twice daily (Sacubitril/Valsartan 24 mg/26 mg)
Maintenance Dose Adjust to 100 mg twice daily (Sacubitril/Valsartan 49 mg/51 mg), as tolerated
Maximum Dose 200 mg twice daily (Sacubitril/Valsartan 97 mg/103 mg), if tolerated

Important Information

  • Renal Impairment: Dose adjustment may be necessary for patients with moderate to severe renal impairment.
  • Hepatic Impairment: For mild hepatic impairment, no dose adjustment is required, but caution should be taken with moderate impairment. Uperio is not recommended for severe hepatic impairment.
  • Use with ACE Inhibitors: Uperio should not be administered with ACE inhibitors due to the risk of angioedema.
  • Monitoring: Regular monitoring of blood pressure, renal function, and potassium levels is recommended during treatment.
  • Pregnancy and Lactation: Uperio should be avoided during pregnancy and breastfeeding.

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