Aquaclav Suspension is a combination antibiotic medication that contains two active ingredients: amoxicillin and clavulanic acid. This powerful combination is designed to effectively combat a wide range of bacterial infections, including respiratory tract infections, skin and soft tissue infections, and urinary tract infections.
Uses
Aquaclav Suspension is indicated for the treatment of various bacterial infections caused by susceptible microorganisms. It is particularly effective against infections caused by beta-lactamase-producing bacteria, which can resist and inactivate certain antibiotics. Some common indications for Aquaclav Suspension include:
- Respiratory tract infections, such as bronchitis, pneumonia, and tonsillitis
- Skin and soft tissue infections, including cellulitis and wound infections
- Urinary tract infections, including cystitis and pyelonephritis
- Ear, nose, and throat infections, such as sinusitis and otitis media
- Intra-abdominal infections, such as peritonitis and diverticulitis
Benefits
Aquaclav Syrup offers several benefits in the treatment of bacterial infections:
- Broad-spectrum activity: The combination of amoxicillin and clavulanic acid provides broad-spectrum coverage against a wide range of gram-positive and gram-negative bacteria, making it an effective treatment option for various types of infections.
- Overcoming antibiotic resistance: Clavulanic acid, a beta-lactamase inhibitor, helps overcome resistance mechanisms employed by some bacteria, extending the efficacy of amoxicillin against resistant strains.
- Convenient liquid formulation: The liquid suspension form of Aquaclav makes it easier to administer, especially for children or patients who have difficulty swallowing tablets or capsules.
- Suitable for outpatient and inpatient settings: Aquaclav Suspension can be prescribed for both outpatient and inpatient treatment of bacterial infections, depending on the severity and site of the infection.
Mechanism of Action
Aquaclav Suspension combines two compounds with different mechanisms of action:
- Amoxicillin: A semi-synthetic penicillin antibiotic, amoxicillin works by inhibiting the synthesis of bacterial cell walls, ultimately leading to cell lysis and death of susceptible bacteria.
- Clavulanic acid: This compound is a beta-lactamase inhibitor, which means it helps protect amoxicillin from being inactivated by certain enzymes (beta-lactamases) produced by some bacteria to resist antibiotics.
By combining amoxicillin with clavulanic acid, Aquaclav Suspension enhances the effectiveness of amoxicillin against a broader range of bacteria, including those that may have developed resistance mechanisms.
Dosage
Based on the amoxicillin component, Aquaclav Suspension should be dosed as follows:
| PATIENT POPULATION | DOSING REGIMEN |
| Aquaclave 125 mg/31.25 mg per 5 mL for oral suspension | |
|
Neonates and Infants aged less than 12 weeks (less than 3 months) |
30 mg/kg/day every 12 hours |
The dosage of Aquaclav Suspension varies depending on the type and severity of the infection, as well as the patient’s age, weight, and renal function. It is typically administered two times daily, with the specific dosage and duration of treatment determined by a healthcare professional.
Side Effects
Like most medications, Aquaclav Suspension may cause side effects. Common side effects may include:
- Gastrointestinal disturbances, such as diarrhea, nausea, and abdominal pain
- Rash or skin reactions
- Headache
- Dizziness
Serious but rare side effects may include:
- Allergic reactions, such as anaphylaxis
- Clostridium difficile-associated diarrhea
- Liver dysfunction
- Kidney dysfunction
Warning
Aquaclav Suspension should be used with caution in patients with known allergies to penicillins or any of the ingredients in the formulation. It should also be used cautiously in patients with impaired renal or hepatic function, as dose adjustments may be necessary.
Important Information
Aquaclav Suspension is a prescription medication and should only be used under the guidance of a qualified healthcare professional. Patients should provide their complete medical history, including any allergies, current medications, and underlying conditions, to ensure safe and effective use of the antibiotic.
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