Disulin 30/70 Insulin (Biphasic) x1

Disulin 30/70 is a biphasic insulin formulation containing 30% soluble insulin (rapid-acting) and 70% isophane insulin (intermediate-acting). This premixed insulin provides both immediate and prolonged blood glucose control for patients with diabetes mellitus.

Uses

Disulin 30/70 is used to treat diabetes mellitus in patients who require insulin therapy. It’s suitable for type 1 diabetes and type 2 diabetes when oral medications are insufficient. This premixed formulation helps maintain blood glucose control throughout the day with fewer injections.

Benefits

• Provides both rapid and intermediate glycemic control
• Reduces number of daily injections needed
• Helps maintain consistent blood glucose levels
• Decreases risk of diabetic complications
• Simplifies insulin regimen for better compliance
• Reduces post-meal glucose spikes
• Provides overnight glucose control
• Suitable for patients with varied insulin requirements
• Cost-effective compared to multiple insulin formulations

How It Works

The soluble insulin component (30%) is rapidly absorbed, controlling blood glucose levels shortly after meals. The isophane insulin (70%) forms crystals at injection sites, releasing gradually over 16-24 hours to provide basal insulin coverage. This combination mimics natural insulin release patterns.

Dosage

Administer subcutaneously 30 minutes before meals, usually breakfast and dinner. Dosage must be individualized based on blood glucose monitoring and clinical response.

Duration of Action

Disulin 30/70 begins working within 30 minutes after injection. The peak action occurs between 2-8 hours. Total duration of action is approximately 16-24 hours. The rapid component targets post-meal glucose while the intermediate component provides coverage between meals and overnight.

Side Effects

Hypoglycemia is the most common side effect. Other potential effects include injection site reactions, weight gain, and allergic responses. Lipodystrophy may occur if injections are repeatedly administered at the same site. Vision changes and edema occasionally occur when starting therapy.

Warning

Never share insulin pens or syringes. Hypoglycemia can be life-threatening; always carry glucose sources. Insulin requirements may change during illness, stress, or changes in physical activity. Regular blood glucose monitoring is essential. Seek medical attention for severe hypoglycemia or persistent hyperglycemia.

Pregnancy and Breastfeeding

Insulin therapy is generally safe during pregnancy and often required for glycemic control. Insulin needs typically increase during pregnancy, especially in the second and third trimesters. Dosage adjustments are common. Breastfeeding is compatible with insulin therapy, though feeding may affect glucose levels.

Interaction

• Beta-blockers may mask hypoglycemia symptoms
• Corticosteroids may increase insulin requirements
• ACE inhibitors may enhance insulin sensitivity
• Thiazolidinediones may cause fluid retention when combined
• Alcohol may enhance and prolong hypoglycemic effect

Precaution

Rotate injection sites to prevent lipodystrophy. Store unopened insulin in refrigerator; in-use vials can remain at room temperature for up to 28 days. Avoid freezing. Inspect insulin for particles or discoloration before use. Patients with renal or hepatic impairment may require dosage adjustments. Always confirm correct insulin type before administration.

Important Information

Disulin 30/70 appears cloudy; gently roll vial to mix before drawing up. Do not shake vigorously. Monitor blood glucose regularly. Carry medical identification indicating diabetes treatment. Never stop insulin without medical supervision. Store away from direct heat and light. Proper injection technique and site rotation are essential for consistent absorption.