Laritin Forte Tablet 80mg/480mg x6

Laritin Forte Tablet contains Artemether (80mg) and Lumefantrine (480mg) in a fixed-dose combination. This antimalarial medication effectively treats acute uncomplicated falciparum malaria, including multi-drug resistant strains of Plasmodium falciparum.

Uses

Laritin Forte Tablet treats acute uncomplicated malaria caused by Plasmodium falciparum. It’s particularly valuable in areas with chloroquine-resistant malaria and is suitable for adults and adolescents. This artemisinin-based combination therapy (ACT) is recommended by WHO for first-line malaria treatment.

Benefits

• Rapidly eliminates malaria parasites from bloodstream
• Effective against multidrug-resistant malaria strains
• Quickly resolves fever and clinical symptoms
• Reduces risk of treatment failure
• Prevents progression to severe malaria
• Minimizes risk of recrudescence
• Well-tolerated compared to older antimalarials
• Shorter treatment duration than many alternatives
• High cure rates in clinical settings

How It Works

Artemether provides rapid parasite clearance by generating free radicals that damage parasite membranes. Lumefantrine has a longer half-life and continues eliminating remaining parasites while preventing recrudescence. This complementary action ensures complete clearance of infection and reduces resistance development.

Dosage

Take with fatty food or milk to enhance absorption. Tablets can be crushed and mixed with water for patients having difficulty swallowing.

Duration of Action

Laritin Forte begins working within hours, with most patients experiencing fever reduction within 24-48 hours. Artemether has a rapid onset with a half-life of 2-3 hours, while lumefantrine provides extended protection for up to 10 days. Complete parasite clearance typically occurs within 3 days.

Side Effects

Most patients tolerate Laritin Forte well. Common side effects include headache, dizziness, fatigue, loss of appetite, nausea, abdominal pain, and sleep disturbances. These typically resolve as treatment progresses. Less common side effects include palpitations, cough, or itching.

Warning

Complete the full 3-day regimen even if symptoms improve quickly. Laritin Forte may prolong QT interval in some patients. Avoid use in patients with congenital QT prolongation or taking medications that affect cardiac conduction. Seek immediate medical attention if experiencing severe vomiting, irregular heartbeat, or seizures.

Pregnancy and Breastfeeding

Laritin Forte is considered safe in the second and third trimesters of pregnancy. First trimester use should be based on clinical judgment when benefits outweigh potential risks. Limited data suggests it’s compatible with breastfeeding, though caution is advised. Consult healthcare provider before use.

Interaction

• Increased risk of QT prolongation with antiarrhythmics and certain antibiotics
• Reduced efficacy when used with CYP3A4 inducers like rifampicin
• Enhanced effects with CYP3A4 inhibitors like ketoconazole
• Potential interaction with hormonal contraceptives
• Grapefruit juice may increase drug concentration and side effects

Precaution

Use with caution in patients with liver or kidney impairment, cardiac conditions, or electrolyte imbalances. Avoid in patients with severe malaria complications, which require parenteral treatment. Those with previous hypersensitivity to artemisinin compounds should not take Laritin Forte. Check for proper diagnosis before initiating treatment.

Important Information

Laritin Forte should be taken with food or milk to maximize absorption. If vomiting occurs within one hour of dosing, repeat the dose. Continue protective measures against mosquito bites. Consult healthcare provider if symptoms persist after treatment. Store below 30°C in original packaging, protected from light and moisture.