Laritin Tablet 20/120mg (Children) x6

Laritin Tablet 20/120mg is a pediatric antimalarial formulation containing artemether and lumefantrine. This combination therapy provides rapid clearance of malaria parasites and is specifically dosed for children weighing between 5kg and 15kg.

Uses

Laritin Tablet 20/120mg treats acute, uncomplicated malaria caused by Plasmodium falciparum in children. It is also effective against mixed infections including P. falciparum and can be used in areas where there is resistance to other antimalarial medications.

Benefits

• Rapid action against malaria parasites
• Effective against drug-resistant strains
• Reduces fever and symptoms quickly
• Prevents progression to severe malaria
• Pediatric-specific dosing
• Combination therapy reduces resistance development
• High cure rates
• Well-tolerated in children

How It Works

Laritin Tablet works through dual mechanisms. Artemether produces rapid reduction of parasite biomass while lumefantrine eliminates remaining parasites. Together they disrupt the parasite’s ability to digest hemoglobin and interfere with nucleic acid and protein synthesis in the malaria parasite.

Duration of Action

Artemether has a rapid onset of action within hours, with a half-life of 2-3 hours. Lumefantrine has a longer half-life of 3-6 days, providing extended protection against recrudescence (return of parasites). Complete course provides therapeutic effects for approximately 4 weeks.

Dosage

Warnings

Do not administer to children with severe malaria requiring parenteral treatment. Not recommended for children weighing less than 5kg. Seek immediate medical attention if symptoms worsen or do not improve within 48 hours. This medication is not for malaria prophylaxis (prevention).

Side Effects

Side effects may include headache, dizziness, loss of appetite, nausea, vomiting, abdominal pain, cough, joint pain, muscle pain, fatigue, sleep disturbances, and mild skin reactions. Most side effects are mild and resolve without intervention.

Pregnancy and Breastfeeding

Not applicable for this pediatric formulation. However, for mothers breastfeeding children receiving this medication, Laritin components may pass into breast milk in small amounts but are generally considered safe.

Interactions

• Antiarrhythmics (risk of QT prolongation)
• Antibiotics like erythromycin, clarithromycin (increased QT interval)
• Antipsychotics (increased risk of cardiac issues)
• CYP3A4 inhibitors (increased drug levels)
• CYP3A4 inducers (decreased effectiveness)
• Antiretrovirals (may alter blood levels)
• Grapefruit juice (may increase drug concentration)

Precautions

Administer with food or milk to enhance absorption and reduce stomach upset. Complete the full 3-day course even if symptoms improve quickly. If vomiting occurs within 1 hour of administration, repeat the dose. Monitor the child for 48 hours after starting treatment to ensure improvement. Keep well hydrated during treatment.

Important Information

Laritin Tablet 20/120mg should be taken at specified intervals (0, 8, 24, 36, 48, and 60 hours) for optimal efficacy. If unable to swallow, tablets can be crushed and mixed with a small amount of water. Treatment should begin as soon as possible after diagnosis for best results.