If Ordered Today We Estimate Delivery By 07, April 2025Rekmal 120mg Injection (Artesunate)
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Rekmal 120mg Injection contains artesunate, a potent and fast-acting artemisinin derivative used for the treatment of severe and life-threatening malaria.
₦7,500.00
Buy NowRekmal 120mg Injection contains artesunate, a potent and fast-acting artemisinin derivative used for the treatment of severe malaria. This injectable medication is particularly valuable in managing life-threatening cases of malaria.
Uses
Rekmal 120mg Injection is primarily used for the initial treatment of severe malaria caused by Plasmodium falciparum. It’s especially crucial in cases where oral medications cannot be administered or rapid action is necessary.
Benefits
- Provides rapid relief from severe malaria symptoms
- Effective against drug-resistant strains of malaria parasites
- Reduces mortality rates in severe malaria cases
- Quickly reduces parasite load in the bloodstream
- Can be used in patients unable to take oral medications
How It Works
Artesunate works by rapidly killing malaria parasites in the blood. It interferes with the parasite’s ability to metabolize heme, leading to the production of free radicals that destroy the parasite.
Dosage
The typical initial dose is 2.4 mg/kg body weight given intravenously or intramuscularly, followed by 2.4 mg/kg at 12 hours and 24 hours. Subsequent doses are given once daily. Treatment should be continued for a minimum of 24 hours until oral therapy can be started.
Side Effects
Common side effects may include nausea, vomiting, and dizziness. Serious side effects, though rare, can include allergic reactions, delayed hemolysis, and neurological effects. Monitor for signs of anemia or neurological symptoms after treatment.
Warning
Rekmal 120mg Injection should be administered by healthcare professionals trained in managing severe malaria. Careful monitoring is required during treatment. It should not be used for malaria prevention or to treat uncomplicated malaria cases.
Pregnancy and Breastfeeding
Rekmal can be used during pregnancy when the potential benefit outweighs the risk, especially in life-threatening situations. Limited data suggest it’s safe during breastfeeding, but caution is advised.
Interaction
- May interact with other antimalarial drugs
- Potential interaction with drugs that affect or are affected by CYP enzymes
- Caution advised when used with drugs that prolong QT interval
- Inform your doctor of all medications you’re taking
Important Information
Rekmal 120mg Injection should be followed by a complete course of an appropriate oral antimalarial treatment. Parasitemia should be monitored regularly during treatment. Adequate supportive care is essential in managing severe malaria. Follow-up assessments are crucial to detect any delayed adverse effects, particularly delayed hemolysis.
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| Category | Dosage Instructions |
|---|---|
| Adults and Children (Severe Malaria) | Initial Dose: 2.4 mg/kg body weight by intravenous (IV) or intramuscular (IM) injection at 0 hours. |
| Follow-up Dose: 2.4 mg/kg at 12 hours, and 24 hours after the initial dose. | |
| Maintenance Dose: 2.4 mg/kg once daily thereafter until oral medication can be started. | |
| Administration Instructions | Administer via slow IV injection (over 1-2 minutes) or IM injection. Reconstitute the injection with 1 ml of 5% sodium bicarbonate solution and dilute further with 5 ml of 0.9% sodium chloride solution for IV use. Use within 1 hour of preparation. |
| Pregnancy and Breastfeeding | Generally considered safe during the second and third trimesters. Use with caution in the first trimester; consult a healthcare provider. |
| Patients with Renal or Hepatic Impairment | No specific dosage adjustment is required; use with caution and monitor for adverse effects. |
Important Notes:
- Indications: Used for the treatment of severe malaria, particularly caused by Plasmodium falciparum.
- Side Effects: Common side effects may include dizziness, headache, nausea, vomiting, and mild injection site pain. Severe side effects may include allergic reactions, delayed hemolytic anemia, or cardiovascular effects. Seek medical attention if severe symptoms occur.
- Contraindications: Not recommended for patients with known hypersensitivity to artesunate or its components.
- Monitoring: Monitor for delayed hemolysis, particularly after treatment, and follow-up with oral antimalarial therapy as recommended by a healthcare provider.
- Storage Instructions: Store in a cool, dry place away from light. Reconstituted solutions should be used immediately or within a short duration as specified by the manufacturer. Keep out of reach of children.
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