Reludrine contains proguanil hydrochloride, a specialized antimalarial agent that effectively prevents and treats malaria. This strategic formulation works by targeting specific metabolic pathways in malarial parasites, providing reliable protection against Plasmodium infections.
Uses
Reludrine serves two primary functions: malaria prevention for travelers to endemic regions and treatment of acute uncomplicated malaria. It’s particularly effective when combined with other antimalarial medications for comprehensive protection.
Benefits
- Effective malaria prevention
- Reliable parasite elimination
- Enhanced treatment efficacy
- Reduced resistance development
- Convenient once-daily dosing
- Well-established safety profile
- Suitable for long-term prophylaxis
- Compatible with other antimalarials
How It Works
Reludrine functions by inhibiting dihydrofolate reductase in malarial parasites, disrupting their folate synthesis pathway. This interference prevents parasite DNA replication and protein synthesis, effectively halting their growth and reproduction.
Duration of Action
Prophylactic protection begins after 1-2 days of use. For optimal prevention, start medication 1-2 weeks before entering malaria-risk areas. Continue for 4 weeks after leaving endemic regions.
Dosage
| Use Case | Daily Dose | Timing | Duration |
|---|---|---|---|
| Prevention | 200mg | Once daily | Throughout exposure |
| Treatment | As prescribed | Once daily | As directed |
| Children | Weight-based | Once daily | As directed |
Side Effects
Generally well-tolerated with minimal adverse effects. Initial gastrointestinal adjustments may occur but typically resolve within days.
Warning
Discontinue and seek immediate medical attention if experiencing severe allergic reactions, unusual bleeding, or persistent fever. Regular monitoring required during treatment.
Pregnancy and Breastfeeding
Safety assessment required for pregnant women. Benefits often outweigh risks in malaria-endemic areas. Discuss with healthcare provider for individualized recommendations.
Interactions
- May interact with warfarin
- Potential effects with folate supplements
- Consider spacing with antacids
- Some antibiotics may affect efficacy
Precautions
Take with food to minimize stomach upset. Maintain consistent dosing schedule. Complete full course of treatment. Monitor for breakthrough symptoms.
Important Information
Store at room temperature (20-25°C) in original container. Protect from moisture and light. Start prophylaxis before entering malaria-risk areas. Continue for prescribed duration after leaving endemic regions. Report unusual symptoms promptly. Keep detailed travel record. Carry medical documentation when traveling. Regular check-ups recommended during long-term use.
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