G-Fluta 250mg Tablet contains flutamide, an antiandrogen medication primarily used in the treatment of prostate cancer. This nonsteroidal antiandrogen works by blocking the effects of androgens (male hormones) in the body. G-Fluta offers an effective treatment option for advanced prostate cancer, often used in combination with other therapies.
Uses Of G-Fluta
G-Fluta 250mg Tablet is primarily used for:
- Treatment of advanced prostate cancer
- Management of metastatic prostate cancer
- Palliative treatment of advanced prostate cancer
- Sometimes used off-label for hirsutism in women
Benefits
- Blocks androgen receptors in prostate cancer cells
- Prevents testosterone flare during LHRH therapy initiation
- Improves survival rates in metastatic prostate cancer
- Reduces prostate-specific antigen (PSA) levels
- Helps control cancer progression and symptoms
- Can be used in combination hormone therapy
- May reduce bone pain from cancer spread
- Provides oral administration convenience
- Well-established safety profile when monitored
How It Works
G-Fluta acts as a competitive antagonist at androgen receptors, blocking testosterone and dihydrotestosterone from binding to these receptors. This prevents androgen-dependent prostate cancer cells from receiving growth signals, thereby inhibiting tumor growth and progression.
Dosage
Patient Group | Standard Dosage | Maximum Daily Dosage |
---|---|---|
Adult Men | 250mg 3× daily | 750mg daily |
Elderly | 250mg 3× daily | 750mg daily |
Take G-Fluta tablets with water at 8-hour intervals. Take with or without food. Maintain consistent timing for optimal effectiveness.
Duration of Action
G-Fluta begins working within hours of administration. Peak plasma concentrations occur within 2-3 hours. The medication must be taken continuously as prescribed. Cancer response typically becomes evident within 4-12 weeks of starting treatment.
Side Effects
Common side effects include hot flashes, breast tenderness, decreased libido, and impotence. Gastrointestinal effects like nausea, diarrhea, or loss of appetite may occur. Gynecomastia (breast enlargement) is frequent. Serious but rare side effects include liver toxicity.
Warning
G-Fluta may cause severe liver injury including hepatic necrosis and death. Regular liver function monitoring is essential. Discontinue immediately if jaundice, dark urine, fatigue, or abdominal pain develops. Not for use in women who are pregnant or may become pregnant.
Pregnancy and Breastfeeding
G-Fluta is contraindicated in pregnant women due to risk of fetal harm and feminization of male fetuses. Women of childbearing potential must use effective contraception. Breastfeeding should be avoided during treatment as the drug may pass into breast milk.
Interaction
- May increase effects of warfarin requiring dose adjustment
- Possible interaction with medications metabolized by CYP1A2
- May affect blood sugar levels in diabetic patients
- Potential interaction with certain antiarrhythmics
- Could alter effectiveness of some antihypertensive medications
- May interact with alcohol increasing liver toxicity risk
Precaution
Regular liver function tests are mandatory during treatment. Monitor for signs of liver toxicity including fatigue, nausea, or jaundice. Use with caution in patients with pre-existing liver disease. Avoid alcohol consumption. Inform all healthcare providers about G-Fluta use before medical procedures.
Important Information
G-Fluta is typically used as part of combination hormone therapy for prostate cancer. Never stop taking without consulting your oncologist. Store at room temperature away from moisture and heat. Keep regular appointments for blood tests and cancer monitoring. Report any unusual symptoms immediately to your healthcare provider. This medication requires specialized oncology care and monitoring.
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