OXYUREA 250mg capsules contain hydroxyurea, a prescription antimetabolite medication designed to slow abnormal cell growth. This therapeutic agent effectively manages chronic myeloid leukemia, polycythemia vera, and sickle cell anemia by regulating blood cell production and preventing complications.
Uses
OXYUREA is prescribed under strict medical supervision for managing serious blood disorders. It helps control chronic myeloid leukemia progression, reduces complications in polycythemia vera, prevents painful crises in sickle cell anemia, and manages conditions where uncontrollable cell growth cannot be surgically addressed.
Benefits
- Effectively targets and suppresses abnormal cell multiplication
- Reduces frequency of painful sickle cell crises
- Decreases need for blood transfusions
- Lowers risk of life-threatening blood clots
- Provides convenient oral administration
- May prevent need for spleen removal surgery
- Extends periods of disease remission
- Improves overall quality of life
How It Works
Hydroxyurea functions as an antimetabolite by interfering with DNA synthesis and repair. It specifically targets rapidly dividing cells, helping to control abnormal cell growth while allowing healthy cells to maintain normal function.
Dosage
| Patient Condition | Age Group | Dosage & Frequency |
|---|---|---|
| Chronic Myeloid Leukemia | Adults | 15-30mg/kg once daily |
| Sickle Cell Anemia | Adults | 15mg/kg once daily |
| Polycythemia Vera | Adults | Initial: 15mg/kg/day, adjusted based on response |
Duration of Action
OXYUREA typically shows initial effects within 2-3 weeks of consistent use. Maximum therapeutic benefits may take 3-6 months to achieve. Regular monitoring and dose adjustments may be necessary throughout treatment.
Side Effects
Common side effects include decreased appetite, nausea, fatigue, and skin changes. More serious effects can involve bone marrow suppression leading to low blood counts. Regular blood monitoring is essential during treatment to manage potential complications.
Warning
Discontinue use and seek immediate medical attention if experiencing severe side effects such as unusual bleeding, persistent fever, or difficulty breathing. OXYUREA should only be taken under close medical supervision.
Pregnancy and Breastfeeding
OXYUREA is contraindicated during pregnancy and breastfeeding due to potential serious risks to the developing fetus or infant. Effective contraception must be used during treatment and for at least 6 months after discontinuation.
Interactions
- May increase toxicity of other chemotherapy drugs
- Can interact with live vaccines
- Potential interaction with antiretroviral medications
- May enhance effects of radiation therapy
Precautions
Regular blood tests are mandatory during treatment. Maintain adequate hydration and follow strict infection prevention measures due to increased susceptibility. Avoid activities that may cause injury due to increased bleeding risk.
Important Information
OXYUREA requires consistent monitoring through blood tests and medical examinations. Never adjust dosage without medical consultation. Store capsules in a cool, dry place away from light. Report any new or worsening symptoms promptly to your healthcare provider.
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