Diamet SR 500mg Tablet (Metformin) x100

Diamet SR 500mg Tablet contains Metformin hydrochloride in a sustained-release formulation. This diabetes medication helps control blood sugar levels in type 2 diabetes patients by improving insulin sensitivity and reducing glucose production by the liver.

Uses

Diamet SR Tablet is used to manage type 2 diabetes mellitus in adults. It helps lower blood glucose levels when diet and exercise alone are insufficient. The medication is often prescribed as first-line treatment for newly diagnosed type 2 diabetes and can be used alone or with other antidiabetic medications.

Benefits

• Effectively lowers blood glucose levels
• Reduces hepatic glucose production
• Improves insulin sensitivity in muscle and fat tissues
• May promote modest weight loss
• Reduces risk of diabetes-related complications
• Does not cause hypoglycemia when used alone
• May improve cardiovascular outcomes
• Sustained-release formulation reduces dosing frequency
• Generally well-tolerated with minimal side effects

How It Works

Diamet SR decreases glucose production in the liver and improves insulin sensitivity in peripheral tissues. Metformin activates AMP-activated protein kinase (AMPK), which inhibits gluconeogenesis and enhances glucose uptake by muscles. The sustained-release formulation provides steady drug levels throughout the day.

Dosage

Take Diamet SR with evening meal to reduce gastrointestinal side effects. Swallow tablets whole; do not crush or chew.

Duration of Action

Diamet SR begins working within hours of administration, with peak effects occurring 4-8 hours after dosing. The sustained-release formulation provides glucose control for 24 hours. Full therapeutic effects typically develop within 2-3 weeks of consistent use.

Side Effects

Common side effects include gastrointestinal disturbances such as nausea, diarrhea, abdominal discomfort, and metallic taste. These usually improve with continued use. Rare but serious side effects include lactic acidosis, which requires immediate medical attention if symptoms like severe weakness, breathing difficulties, or unusual muscle pain occur.

Warning

Risk of lactic acidosis exists, particularly in patients with kidney or liver impairment, heart failure, or during illness causing dehydration. Discontinue before contrast procedures and restart only after normal kidney function is confirmed. Monitor kidney function regularly. Seek immediate medical care for symptoms of lactic acidosis.

Pregnancy and Breastfeeding

Diamet SR is generally considered safe during pregnancy and is often preferred over insulin for gestational diabetes management. The medication passes into breast milk in small amounts but is considered compatible with breastfeeding. Consult healthcare provider for personalized guidance.

Interaction

• May increase risk of lactic acidosis with alcohol consumption
• Contrast agents may increase risk of kidney problems
• Certain medications may increase or decrease Metformin levels
• May enhance effects of other antidiabetic medications
• Potential interaction with some blood pressure medications
• Vitamin B12 absorption may be reduced with long-term use

Precaution

Regular monitoring of kidney function is essential. Use with caution in elderly patients and those with liver disease. Temporarily discontinue during surgical procedures, serious infections, or dehydration. Inform all healthcare providers about Diamet SR use before any medical procedures or imaging studies.

Important Information

Diamet SR is most effective when combined with proper diet and regular exercise. Monitor blood glucose levels regularly as directed by your healthcare provider. Store at room temperature away from moisture and heat. Do not stop taking suddenly without medical supervision. Carry identification indicating diabetes medication use in case of emergency.